Urine Xanthine Crystals in Hematologic Malignancies with Tumor Lysis Syndrome

Tumor lysis syndrome (TLS) is a metabolic disorder caused by massive tumor lysis. Hypouricemic agents are administered to prevent TLS-related hyperuricemia and renal failure. We experienced three cases of urine xanthine crystals during TLS in patients with hematologic malignancies who received proph...

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Autores principales: Ito, Shoko, Fujiwara, Shin-ichiro, Yoshizawa, Tomoaki, Hayatsu, Kaori, Sekiguchi, Kaoru, Murahashi, Rui, Nakashima, Hirotomo, Matsuoka, Sae, Ikeda, Takashi, Toda, Yumiko, Kawaguchi, Shinichiro, Nagayama, Takashi, Umino, Kento, Minakata, Daisuke, Nakano, Hirofumi, Morita, Kaoru, Yamasaki, Ryoko, Ashizawa, Masahiro, Yamamoto, Chihiro, Hatano, Kaoru, Sato, Kazuya, Ohmine, Ken, Kanda, Yoshinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683812/
https://www.ncbi.nlm.nih.gov/pubmed/35370238
http://dx.doi.org/10.2169/internalmedicine.9332-22
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author Ito, Shoko
Fujiwara, Shin-ichiro
Yoshizawa, Tomoaki
Hayatsu, Kaori
Sekiguchi, Kaoru
Murahashi, Rui
Nakashima, Hirotomo
Matsuoka, Sae
Ikeda, Takashi
Toda, Yumiko
Kawaguchi, Shinichiro
Nagayama, Takashi
Umino, Kento
Minakata, Daisuke
Nakano, Hirofumi
Morita, Kaoru
Yamasaki, Ryoko
Ashizawa, Masahiro
Yamamoto, Chihiro
Hatano, Kaoru
Sato, Kazuya
Ohmine, Ken
Kanda, Yoshinobu
author_facet Ito, Shoko
Fujiwara, Shin-ichiro
Yoshizawa, Tomoaki
Hayatsu, Kaori
Sekiguchi, Kaoru
Murahashi, Rui
Nakashima, Hirotomo
Matsuoka, Sae
Ikeda, Takashi
Toda, Yumiko
Kawaguchi, Shinichiro
Nagayama, Takashi
Umino, Kento
Minakata, Daisuke
Nakano, Hirofumi
Morita, Kaoru
Yamasaki, Ryoko
Ashizawa, Masahiro
Yamamoto, Chihiro
Hatano, Kaoru
Sato, Kazuya
Ohmine, Ken
Kanda, Yoshinobu
author_sort Ito, Shoko
collection PubMed
description Tumor lysis syndrome (TLS) is a metabolic disorder caused by massive tumor lysis. Hypouricemic agents are administered to prevent TLS-related hyperuricemia and renal failure. We experienced three cases of urine xanthine crystals during TLS in patients with hematologic malignancies who received prophylactic febuxostat. Yellowish and pinkish deposits were observed in urinary tract catheters and urinary bags. Urine microscopy revealed that the deposits were xanthine crystals. In rapid tumor lysis, inhibition of xanthine oxidase can cause xanthine accumulation and urine xanthine crystallization. During TLS, urine xanthine crystals may be overlooked, so careful observation and management are required to avoid xanthine nephropathy.
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spelling pubmed-96838122022-12-02 Urine Xanthine Crystals in Hematologic Malignancies with Tumor Lysis Syndrome Ito, Shoko Fujiwara, Shin-ichiro Yoshizawa, Tomoaki Hayatsu, Kaori Sekiguchi, Kaoru Murahashi, Rui Nakashima, Hirotomo Matsuoka, Sae Ikeda, Takashi Toda, Yumiko Kawaguchi, Shinichiro Nagayama, Takashi Umino, Kento Minakata, Daisuke Nakano, Hirofumi Morita, Kaoru Yamasaki, Ryoko Ashizawa, Masahiro Yamamoto, Chihiro Hatano, Kaoru Sato, Kazuya Ohmine, Ken Kanda, Yoshinobu Intern Med Case Report Tumor lysis syndrome (TLS) is a metabolic disorder caused by massive tumor lysis. Hypouricemic agents are administered to prevent TLS-related hyperuricemia and renal failure. We experienced three cases of urine xanthine crystals during TLS in patients with hematologic malignancies who received prophylactic febuxostat. Yellowish and pinkish deposits were observed in urinary tract catheters and urinary bags. Urine microscopy revealed that the deposits were xanthine crystals. In rapid tumor lysis, inhibition of xanthine oxidase can cause xanthine accumulation and urine xanthine crystallization. During TLS, urine xanthine crystals may be overlooked, so careful observation and management are required to avoid xanthine nephropathy. The Japanese Society of Internal Medicine 2022-04-02 2022-11-01 /pmc/articles/PMC9683812/ /pubmed/35370238 http://dx.doi.org/10.2169/internalmedicine.9332-22 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ito, Shoko
Fujiwara, Shin-ichiro
Yoshizawa, Tomoaki
Hayatsu, Kaori
Sekiguchi, Kaoru
Murahashi, Rui
Nakashima, Hirotomo
Matsuoka, Sae
Ikeda, Takashi
Toda, Yumiko
Kawaguchi, Shinichiro
Nagayama, Takashi
Umino, Kento
Minakata, Daisuke
Nakano, Hirofumi
Morita, Kaoru
Yamasaki, Ryoko
Ashizawa, Masahiro
Yamamoto, Chihiro
Hatano, Kaoru
Sato, Kazuya
Ohmine, Ken
Kanda, Yoshinobu
Urine Xanthine Crystals in Hematologic Malignancies with Tumor Lysis Syndrome
title Urine Xanthine Crystals in Hematologic Malignancies with Tumor Lysis Syndrome
title_full Urine Xanthine Crystals in Hematologic Malignancies with Tumor Lysis Syndrome
title_fullStr Urine Xanthine Crystals in Hematologic Malignancies with Tumor Lysis Syndrome
title_full_unstemmed Urine Xanthine Crystals in Hematologic Malignancies with Tumor Lysis Syndrome
title_short Urine Xanthine Crystals in Hematologic Malignancies with Tumor Lysis Syndrome
title_sort urine xanthine crystals in hematologic malignancies with tumor lysis syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683812/
https://www.ncbi.nlm.nih.gov/pubmed/35370238
http://dx.doi.org/10.2169/internalmedicine.9332-22
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