Complete Bone Marrow Necrosis with Charcot-Leyden Crystals Caused by Myeloid Neoplasm with Mutated NPM1 and TET2

Bone marrow necrosis (BMN) has various underlying diseases. In hematological malignancies, both lymphoid and myeloid neoplasms have been shown to cause BMN. Charcot-Leyden crystals (CLCs) are bipyramidal crystals that have been found in patients with immune system diseases, tumors, skin diseases, as...

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Autores principales: Saito, Kenki, Sato, Takayuki, Notohara, Kenji, Nannya, Yasuhito, Ogawa, Seishi, Ueda, Yasunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683816/
https://www.ncbi.nlm.nih.gov/pubmed/35185048
http://dx.doi.org/10.2169/internalmedicine.8859-21
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author Saito, Kenki
Sato, Takayuki
Notohara, Kenji
Nannya, Yasuhito
Ogawa, Seishi
Ueda, Yasunori
author_facet Saito, Kenki
Sato, Takayuki
Notohara, Kenji
Nannya, Yasuhito
Ogawa, Seishi
Ueda, Yasunori
author_sort Saito, Kenki
collection PubMed
description Bone marrow necrosis (BMN) has various underlying diseases. In hematological malignancies, both lymphoid and myeloid neoplasms have been shown to cause BMN. Charcot-Leyden crystals (CLCs) are bipyramidal crystals that have been found in patients with immune system diseases, tumors, skin diseases, asthma, infections, and intestinal diseases. Because the combination of CLCs and acute myeloid leukemia (AML) is rare, the relationship between BMN, CLCs, and AML remains largely unexplored. We herein report a suspected case of AML that was difficult to diagnose morphologically because of complete BMN with CLCs but achieved complete hematologic remission with treatment similar to that for AML.
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spelling pubmed-96838162022-12-02 Complete Bone Marrow Necrosis with Charcot-Leyden Crystals Caused by Myeloid Neoplasm with Mutated NPM1 and TET2 Saito, Kenki Sato, Takayuki Notohara, Kenji Nannya, Yasuhito Ogawa, Seishi Ueda, Yasunori Intern Med Case Report Bone marrow necrosis (BMN) has various underlying diseases. In hematological malignancies, both lymphoid and myeloid neoplasms have been shown to cause BMN. Charcot-Leyden crystals (CLCs) are bipyramidal crystals that have been found in patients with immune system diseases, tumors, skin diseases, asthma, infections, and intestinal diseases. Because the combination of CLCs and acute myeloid leukemia (AML) is rare, the relationship between BMN, CLCs, and AML remains largely unexplored. We herein report a suspected case of AML that was difficult to diagnose morphologically because of complete BMN with CLCs but achieved complete hematologic remission with treatment similar to that for AML. The Japanese Society of Internal Medicine 2022-02-19 2022-11-01 /pmc/articles/PMC9683816/ /pubmed/35185048 http://dx.doi.org/10.2169/internalmedicine.8859-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Saito, Kenki
Sato, Takayuki
Notohara, Kenji
Nannya, Yasuhito
Ogawa, Seishi
Ueda, Yasunori
Complete Bone Marrow Necrosis with Charcot-Leyden Crystals Caused by Myeloid Neoplasm with Mutated NPM1 and TET2
title Complete Bone Marrow Necrosis with Charcot-Leyden Crystals Caused by Myeloid Neoplasm with Mutated NPM1 and TET2
title_full Complete Bone Marrow Necrosis with Charcot-Leyden Crystals Caused by Myeloid Neoplasm with Mutated NPM1 and TET2
title_fullStr Complete Bone Marrow Necrosis with Charcot-Leyden Crystals Caused by Myeloid Neoplasm with Mutated NPM1 and TET2
title_full_unstemmed Complete Bone Marrow Necrosis with Charcot-Leyden Crystals Caused by Myeloid Neoplasm with Mutated NPM1 and TET2
title_short Complete Bone Marrow Necrosis with Charcot-Leyden Crystals Caused by Myeloid Neoplasm with Mutated NPM1 and TET2
title_sort complete bone marrow necrosis with charcot-leyden crystals caused by myeloid neoplasm with mutated npm1 and tet2
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683816/
https://www.ncbi.nlm.nih.gov/pubmed/35185048
http://dx.doi.org/10.2169/internalmedicine.8859-21
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