Pembrolizumab-induced Myasthenia Gravis Relapse after Immunosuppressive Therapy

Myasthenia gravis (MG) is an immune-related adverse event (irAE), and as an irAE, MG (irAE-MG) generally has a monophasic course, with only a few case reports of irAE-MG flare-ups during the course of the disease. We herein report a case of pembrolizumab-induced MG with relapsing symptoms. irAE-MG i...

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Autores principales: Oshima, Yuki, Fujii, Shintaro, Horiuchi, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683818/
https://www.ncbi.nlm.nih.gov/pubmed/35400705
http://dx.doi.org/10.2169/internalmedicine.8554-21
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author Oshima, Yuki
Fujii, Shintaro
Horiuchi, Kazuhiro
author_facet Oshima, Yuki
Fujii, Shintaro
Horiuchi, Kazuhiro
author_sort Oshima, Yuki
collection PubMed
description Myasthenia gravis (MG) is an immune-related adverse event (irAE), and as an irAE, MG (irAE-MG) generally has a monophasic course, with only a few case reports of irAE-MG flare-ups during the course of the disease. We herein report a case of pembrolizumab-induced MG with relapsing symptoms. irAE-MG is a rare disease that has not yet been fully characterized, and our case shows that MG symptoms may relapse. Therefore, regular follow-up is necessary, even after the symptoms improve with immunosuppressive therapy.
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spelling pubmed-96838182022-12-02 Pembrolizumab-induced Myasthenia Gravis Relapse after Immunosuppressive Therapy Oshima, Yuki Fujii, Shintaro Horiuchi, Kazuhiro Intern Med Case Report Myasthenia gravis (MG) is an immune-related adverse event (irAE), and as an irAE, MG (irAE-MG) generally has a monophasic course, with only a few case reports of irAE-MG flare-ups during the course of the disease. We herein report a case of pembrolizumab-induced MG with relapsing symptoms. irAE-MG is a rare disease that has not yet been fully characterized, and our case shows that MG symptoms may relapse. Therefore, regular follow-up is necessary, even after the symptoms improve with immunosuppressive therapy. The Japanese Society of Internal Medicine 2022-04-09 2022-11-01 /pmc/articles/PMC9683818/ /pubmed/35400705 http://dx.doi.org/10.2169/internalmedicine.8554-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Oshima, Yuki
Fujii, Shintaro
Horiuchi, Kazuhiro
Pembrolizumab-induced Myasthenia Gravis Relapse after Immunosuppressive Therapy
title Pembrolizumab-induced Myasthenia Gravis Relapse after Immunosuppressive Therapy
title_full Pembrolizumab-induced Myasthenia Gravis Relapse after Immunosuppressive Therapy
title_fullStr Pembrolizumab-induced Myasthenia Gravis Relapse after Immunosuppressive Therapy
title_full_unstemmed Pembrolizumab-induced Myasthenia Gravis Relapse after Immunosuppressive Therapy
title_short Pembrolizumab-induced Myasthenia Gravis Relapse after Immunosuppressive Therapy
title_sort pembrolizumab-induced myasthenia gravis relapse after immunosuppressive therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683818/
https://www.ncbi.nlm.nih.gov/pubmed/35400705
http://dx.doi.org/10.2169/internalmedicine.8554-21
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AT fujiishintaro pembrolizumabinducedmyastheniagravisrelapseafterimmunosuppressivetherapy
AT horiuchikazuhiro pembrolizumabinducedmyastheniagravisrelapseafterimmunosuppressivetherapy

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