Ultra-magnifying Imaging of Thoracoscopic Biopsy Specimens Using Ex vivo Endocytoscopy in Three Patients with Mesothelioma

We performed endocytoscopy (ECS) for the ex vivo evaluation of mesothelioma in specimens biopsied during medical thoracoscopy in three patients. We evaluated 19 biopsy specimens based on the density of nuclei and irregularity in the nuclei shape using ECS and compared them with the histopathological...

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Autores principales: Shiratsuki, Yohei, Kurimoto, Noriaki, Amano, Yoshihiro, Hamaguchi, Shunichi, Kobayashi, Misato, Okuno, Takae, Hotta, Takamasa, Tsubata, Yukari, Isobe, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683823/
https://www.ncbi.nlm.nih.gov/pubmed/36328587
http://dx.doi.org/10.2169/internalmedicine.9173-21
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author Shiratsuki, Yohei
Kurimoto, Noriaki
Amano, Yoshihiro
Hamaguchi, Shunichi
Kobayashi, Misato
Okuno, Takae
Hotta, Takamasa
Tsubata, Yukari
Isobe, Takeshi
author_facet Shiratsuki, Yohei
Kurimoto, Noriaki
Amano, Yoshihiro
Hamaguchi, Shunichi
Kobayashi, Misato
Okuno, Takae
Hotta, Takamasa
Tsubata, Yukari
Isobe, Takeshi
author_sort Shiratsuki, Yohei
collection PubMed
description We performed endocytoscopy (ECS) for the ex vivo evaluation of mesothelioma in specimens biopsied during medical thoracoscopy in three patients. We evaluated 19 biopsy specimens based on the density of nuclei and irregularity in the nuclei shape using ECS and compared them with the histopathological findings. All 10 specimens considered malignant based on ECS were diagnosed as malignant based on histopathology. The nine specimens evaluated as non-malignant based on ECS consisted of six specimens diagnosed as malignant based on histopathology and three diagnosed as non-malignant based on histopathology. ECS was feasible and had some utility for ex vivo ultra-magnifying imaging of thoracoscopic biopsy specimens from patients with mesothelioma.
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spelling pubmed-96838232022-12-02 Ultra-magnifying Imaging of Thoracoscopic Biopsy Specimens Using Ex vivo Endocytoscopy in Three Patients with Mesothelioma Shiratsuki, Yohei Kurimoto, Noriaki Amano, Yoshihiro Hamaguchi, Shunichi Kobayashi, Misato Okuno, Takae Hotta, Takamasa Tsubata, Yukari Isobe, Takeshi Intern Med Case Report We performed endocytoscopy (ECS) for the ex vivo evaluation of mesothelioma in specimens biopsied during medical thoracoscopy in three patients. We evaluated 19 biopsy specimens based on the density of nuclei and irregularity in the nuclei shape using ECS and compared them with the histopathological findings. All 10 specimens considered malignant based on ECS were diagnosed as malignant based on histopathology. The nine specimens evaluated as non-malignant based on ECS consisted of six specimens diagnosed as malignant based on histopathology and three diagnosed as non-malignant based on histopathology. ECS was feasible and had some utility for ex vivo ultra-magnifying imaging of thoracoscopic biopsy specimens from patients with mesothelioma. The Japanese Society of Internal Medicine 2022-11-01 /pmc/articles/PMC9683823/ /pubmed/36328587 http://dx.doi.org/10.2169/internalmedicine.9173-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Shiratsuki, Yohei
Kurimoto, Noriaki
Amano, Yoshihiro
Hamaguchi, Shunichi
Kobayashi, Misato
Okuno, Takae
Hotta, Takamasa
Tsubata, Yukari
Isobe, Takeshi
Ultra-magnifying Imaging of Thoracoscopic Biopsy Specimens Using Ex vivo Endocytoscopy in Three Patients with Mesothelioma
title Ultra-magnifying Imaging of Thoracoscopic Biopsy Specimens Using Ex vivo Endocytoscopy in Three Patients with Mesothelioma
title_full Ultra-magnifying Imaging of Thoracoscopic Biopsy Specimens Using Ex vivo Endocytoscopy in Three Patients with Mesothelioma
title_fullStr Ultra-magnifying Imaging of Thoracoscopic Biopsy Specimens Using Ex vivo Endocytoscopy in Three Patients with Mesothelioma
title_full_unstemmed Ultra-magnifying Imaging of Thoracoscopic Biopsy Specimens Using Ex vivo Endocytoscopy in Three Patients with Mesothelioma
title_short Ultra-magnifying Imaging of Thoracoscopic Biopsy Specimens Using Ex vivo Endocytoscopy in Three Patients with Mesothelioma
title_sort ultra-magnifying imaging of thoracoscopic biopsy specimens using ex vivo endocytoscopy in three patients with mesothelioma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683823/
https://www.ncbi.nlm.nih.gov/pubmed/36328587
http://dx.doi.org/10.2169/internalmedicine.9173-21
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