Human 14-3-3 Proteins Site-selectively Bind the Mutational Hotspot Region of SARS-CoV-2 Nucleoprotein Modulating its Phosphoregulation

Phosphorylation of SARS-CoV-2 nucleoprotein recruits human cytosolic 14-3-3 proteins playing a well-recognized role in replication of many viruses. Here we use genetic code expansion to demonstrate that 14-3-3 binding is triggered by phosphorylation of SARS-CoV-2 nucleoprotein at either of two pseud...

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Detalles Bibliográficos
Autores principales: Tugaeva, Kristina V., Sysoev, Andrey A., Kapitonova, Anna A., Smith, Jake L.R., Zhu, Phillip, Cooley, Richard B., Antson, Alfred A., Sluchanko, Nikolai N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683861/
https://www.ncbi.nlm.nih.gov/pubmed/36427566
http://dx.doi.org/10.1016/j.jmb.2022.167891

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