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Risk of premature coronary atherosclerosis in patients with nonalcoholic fatty liver disease
OBJECTIVE: In the current literature, there are few studies investigating the relationship between premature coronary atherosclerosis and nonalcoholic fatty liver disease. We aimed to evaluate the relationship between nonalcoholic fatty liver disease and premature coronary atherosclerosis. METHODS:...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Médica Brasileira
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683909/ https://www.ncbi.nlm.nih.gov/pubmed/36417648 http://dx.doi.org/10.1590/1806-9282.20220514 |
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author | Taylan, Gökay Ebik, Mustafa Solak, Serdar Kaya, Çağlar Yalta, Kenan |
author_facet | Taylan, Gökay Ebik, Mustafa Solak, Serdar Kaya, Çağlar Yalta, Kenan |
author_sort | Taylan, Gökay |
collection | PubMed |
description | OBJECTIVE: In the current literature, there are few studies investigating the relationship between premature coronary atherosclerosis and nonalcoholic fatty liver disease. We aimed to evaluate the relationship between nonalcoholic fatty liver disease and premature coronary atherosclerosis. METHODS: In this cross-sectional study, female patients aged <55 years and male patients aged <50 years were enrolled. Both male and female patients underwent coronary angiography and abdomen ultrasonography between 2014 and 2019. A stepwise binary logistic regression analysis was carried out to evaluate the independent variables related to premature coronary atherosclerosis and nonalcoholic fatty liver disease. A p-value<0.05 was considered statistically significant. RESULTS: nonalcoholic fatty liver disease was present in 44% of patients (n=377). Notably, 62% of the patients were female and the mean age was 44.5 (39–49) years. In a multivariate analysis, nonalcoholic fatty liver disease was shown to be an independent risk factor of premature coronary atherosclerosis (OR 1.438; 95%CI, 1.050–1.969; p=0.024). CONCLUSIONS: The presence of nonalcoholic fatty liver disease is an important independent risk factor for the development of premature coronary atherosclerosis. |
format | Online Article Text |
id | pubmed-9683909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Associação Médica Brasileira |
record_format | MEDLINE/PubMed |
spelling | pubmed-96839092022-11-25 Risk of premature coronary atherosclerosis in patients with nonalcoholic fatty liver disease Taylan, Gökay Ebik, Mustafa Solak, Serdar Kaya, Çağlar Yalta, Kenan Rev Assoc Med Bras (1992) Original Article OBJECTIVE: In the current literature, there are few studies investigating the relationship between premature coronary atherosclerosis and nonalcoholic fatty liver disease. We aimed to evaluate the relationship between nonalcoholic fatty liver disease and premature coronary atherosclerosis. METHODS: In this cross-sectional study, female patients aged <55 years and male patients aged <50 years were enrolled. Both male and female patients underwent coronary angiography and abdomen ultrasonography between 2014 and 2019. A stepwise binary logistic regression analysis was carried out to evaluate the independent variables related to premature coronary atherosclerosis and nonalcoholic fatty liver disease. A p-value<0.05 was considered statistically significant. RESULTS: nonalcoholic fatty liver disease was present in 44% of patients (n=377). Notably, 62% of the patients were female and the mean age was 44.5 (39–49) years. In a multivariate analysis, nonalcoholic fatty liver disease was shown to be an independent risk factor of premature coronary atherosclerosis (OR 1.438; 95%CI, 1.050–1.969; p=0.024). CONCLUSIONS: The presence of nonalcoholic fatty liver disease is an important independent risk factor for the development of premature coronary atherosclerosis. Associação Médica Brasileira 2022-11-21 /pmc/articles/PMC9683909/ /pubmed/36417648 http://dx.doi.org/10.1590/1806-9282.20220514 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Taylan, Gökay Ebik, Mustafa Solak, Serdar Kaya, Çağlar Yalta, Kenan Risk of premature coronary atherosclerosis in patients with nonalcoholic fatty liver disease |
title | Risk of premature coronary atherosclerosis in patients with nonalcoholic fatty liver disease |
title_full | Risk of premature coronary atherosclerosis in patients with nonalcoholic fatty liver disease |
title_fullStr | Risk of premature coronary atherosclerosis in patients with nonalcoholic fatty liver disease |
title_full_unstemmed | Risk of premature coronary atherosclerosis in patients with nonalcoholic fatty liver disease |
title_short | Risk of premature coronary atherosclerosis in patients with nonalcoholic fatty liver disease |
title_sort | risk of premature coronary atherosclerosis in patients with nonalcoholic fatty liver disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683909/ https://www.ncbi.nlm.nih.gov/pubmed/36417648 http://dx.doi.org/10.1590/1806-9282.20220514 |
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