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Evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia

OBJECTIVE: This study aimed to assess the patterns of serum cytokines in chronic lymphocytic leukemia patients at baseline and post-chemotherapy and investigate their association with response to treatment and chronic lymphocytic leukemia prognosis. METHODS: Blood samples were taken from 32 subjects...

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Autores principales: Khodashenas, Maryam, Rajabian, Arezoo, Attaranzadeh, Armin, Lavi Arab, Fahimeh, Allahyari, Negin, Allahyari, Abolghasem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Médica Brasileira 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683924/
https://www.ncbi.nlm.nih.gov/pubmed/36417637
http://dx.doi.org/10.1590/1806-9282.20220260
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author Khodashenas, Maryam
Rajabian, Arezoo
Attaranzadeh, Armin
Lavi Arab, Fahimeh
Allahyari, Negin
Allahyari, Abolghasem
author_facet Khodashenas, Maryam
Rajabian, Arezoo
Attaranzadeh, Armin
Lavi Arab, Fahimeh
Allahyari, Negin
Allahyari, Abolghasem
author_sort Khodashenas, Maryam
collection PubMed
description OBJECTIVE: This study aimed to assess the patterns of serum cytokines in chronic lymphocytic leukemia patients at baseline and post-chemotherapy and investigate their association with response to treatment and chronic lymphocytic leukemia prognosis. METHODS: Blood samples were taken from 32 subjects at their first medical visit after being diagnosed with chronic lymphocytic leukemia and 1 year after chemotherapy. Then, levels of cytokines and blood parameters in peripheral blood were measured. Correlation analysis was used to assess the indexes before and after chemotherapy as well as at different disease stages. RESULTS: Most of the patients (45.80%) had stages I and III before initiation of treatment and after treatment, respectively. There were significant differences between levels of interleukin (IL)-6 (p=0.006) and IL-10 (p=0.009) before and after treatment. Notably, the difference in IL-10 levels before and after treatment was significantly higher in the advanced stages compared to that in the non-advanced stages (p=0.007). IL-6 and IL-10 were also higher in the expired patients compared to the survived cases. CONCLUSIONS: Cytokines such as IL-6 and IL-10 may be considered predicting factors for chronic lymphocytic leukemia prognosis.
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spelling pubmed-96839242022-11-25 Evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia Khodashenas, Maryam Rajabian, Arezoo Attaranzadeh, Armin Lavi Arab, Fahimeh Allahyari, Negin Allahyari, Abolghasem Rev Assoc Med Bras (1992) Original Article OBJECTIVE: This study aimed to assess the patterns of serum cytokines in chronic lymphocytic leukemia patients at baseline and post-chemotherapy and investigate their association with response to treatment and chronic lymphocytic leukemia prognosis. METHODS: Blood samples were taken from 32 subjects at their first medical visit after being diagnosed with chronic lymphocytic leukemia and 1 year after chemotherapy. Then, levels of cytokines and blood parameters in peripheral blood were measured. Correlation analysis was used to assess the indexes before and after chemotherapy as well as at different disease stages. RESULTS: Most of the patients (45.80%) had stages I and III before initiation of treatment and after treatment, respectively. There were significant differences between levels of interleukin (IL)-6 (p=0.006) and IL-10 (p=0.009) before and after treatment. Notably, the difference in IL-10 levels before and after treatment was significantly higher in the advanced stages compared to that in the non-advanced stages (p=0.007). IL-6 and IL-10 were also higher in the expired patients compared to the survived cases. CONCLUSIONS: Cytokines such as IL-6 and IL-10 may be considered predicting factors for chronic lymphocytic leukemia prognosis. Associação Médica Brasileira 2022-11-21 /pmc/articles/PMC9683924/ /pubmed/36417637 http://dx.doi.org/10.1590/1806-9282.20220260 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Khodashenas, Maryam
Rajabian, Arezoo
Attaranzadeh, Armin
Lavi Arab, Fahimeh
Allahyari, Negin
Allahyari, Abolghasem
Evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia
title Evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia
title_full Evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia
title_fullStr Evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia
title_full_unstemmed Evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia
title_short Evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia
title_sort evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683924/
https://www.ncbi.nlm.nih.gov/pubmed/36417637
http://dx.doi.org/10.1590/1806-9282.20220260
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