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Evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia
OBJECTIVE: This study aimed to assess the patterns of serum cytokines in chronic lymphocytic leukemia patients at baseline and post-chemotherapy and investigate their association with response to treatment and chronic lymphocytic leukemia prognosis. METHODS: Blood samples were taken from 32 subjects...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Médica Brasileira
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683924/ https://www.ncbi.nlm.nih.gov/pubmed/36417637 http://dx.doi.org/10.1590/1806-9282.20220260 |
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author | Khodashenas, Maryam Rajabian, Arezoo Attaranzadeh, Armin Lavi Arab, Fahimeh Allahyari, Negin Allahyari, Abolghasem |
author_facet | Khodashenas, Maryam Rajabian, Arezoo Attaranzadeh, Armin Lavi Arab, Fahimeh Allahyari, Negin Allahyari, Abolghasem |
author_sort | Khodashenas, Maryam |
collection | PubMed |
description | OBJECTIVE: This study aimed to assess the patterns of serum cytokines in chronic lymphocytic leukemia patients at baseline and post-chemotherapy and investigate their association with response to treatment and chronic lymphocytic leukemia prognosis. METHODS: Blood samples were taken from 32 subjects at their first medical visit after being diagnosed with chronic lymphocytic leukemia and 1 year after chemotherapy. Then, levels of cytokines and blood parameters in peripheral blood were measured. Correlation analysis was used to assess the indexes before and after chemotherapy as well as at different disease stages. RESULTS: Most of the patients (45.80%) had stages I and III before initiation of treatment and after treatment, respectively. There were significant differences between levels of interleukin (IL)-6 (p=0.006) and IL-10 (p=0.009) before and after treatment. Notably, the difference in IL-10 levels before and after treatment was significantly higher in the advanced stages compared to that in the non-advanced stages (p=0.007). IL-6 and IL-10 were also higher in the expired patients compared to the survived cases. CONCLUSIONS: Cytokines such as IL-6 and IL-10 may be considered predicting factors for chronic lymphocytic leukemia prognosis. |
format | Online Article Text |
id | pubmed-9683924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Associação Médica Brasileira |
record_format | MEDLINE/PubMed |
spelling | pubmed-96839242022-11-25 Evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia Khodashenas, Maryam Rajabian, Arezoo Attaranzadeh, Armin Lavi Arab, Fahimeh Allahyari, Negin Allahyari, Abolghasem Rev Assoc Med Bras (1992) Original Article OBJECTIVE: This study aimed to assess the patterns of serum cytokines in chronic lymphocytic leukemia patients at baseline and post-chemotherapy and investigate their association with response to treatment and chronic lymphocytic leukemia prognosis. METHODS: Blood samples were taken from 32 subjects at their first medical visit after being diagnosed with chronic lymphocytic leukemia and 1 year after chemotherapy. Then, levels of cytokines and blood parameters in peripheral blood were measured. Correlation analysis was used to assess the indexes before and after chemotherapy as well as at different disease stages. RESULTS: Most of the patients (45.80%) had stages I and III before initiation of treatment and after treatment, respectively. There were significant differences between levels of interleukin (IL)-6 (p=0.006) and IL-10 (p=0.009) before and after treatment. Notably, the difference in IL-10 levels before and after treatment was significantly higher in the advanced stages compared to that in the non-advanced stages (p=0.007). IL-6 and IL-10 were also higher in the expired patients compared to the survived cases. CONCLUSIONS: Cytokines such as IL-6 and IL-10 may be considered predicting factors for chronic lymphocytic leukemia prognosis. Associação Médica Brasileira 2022-11-21 /pmc/articles/PMC9683924/ /pubmed/36417637 http://dx.doi.org/10.1590/1806-9282.20220260 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Khodashenas, Maryam Rajabian, Arezoo Attaranzadeh, Armin Lavi Arab, Fahimeh Allahyari, Negin Allahyari, Abolghasem Evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia |
title | Evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia |
title_full | Evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia |
title_fullStr | Evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia |
title_full_unstemmed | Evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia |
title_short | Evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia |
title_sort | evaluation of cytokine levels as possible predicting elements in patients with chronic lymphocytic leukemia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683924/ https://www.ncbi.nlm.nih.gov/pubmed/36417637 http://dx.doi.org/10.1590/1806-9282.20220260 |
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