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Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach

BACKGROUND: Xieriga-4 decoction (XRG-4) is a classic prescription Mongolian medicine that has potent diuretic and anti-inflammatory activities. However, its functional components remain unknown. PURPOSE: This study aimed to identify the chemical components in XRG-4 and its metabolome in vivo. METHOD...

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Detalles Bibliográficos
Autores principales: Ma, Yuanyuan, Ma, Ruiting, ZhiGui, Sa, QiLa, Zhao, Na, Wurigumala, Burentegusi, Guo, Zhigang, Tumenwuliji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683986/
https://www.ncbi.nlm.nih.gov/pubmed/36437832
http://dx.doi.org/10.1155/2022/8197364
Descripción
Sumario:BACKGROUND: Xieriga-4 decoction (XRG-4) is a classic prescription Mongolian medicine that has potent diuretic and anti-inflammatory activities. However, its functional components remain unknown. PURPOSE: This study aimed to identify the chemical components in XRG-4 and its metabolome in vivo. METHODS: An ultra-performance liquid chromatography coupled with a quadrupole time-of-flight tandem mass spectrometry based approach was proposed to systematically profile the chemicolome and metabolome of XRG-4. RESULT: A total of 106 constituents were identified in XRG-4. Eighty-nine components were identified in biological samples, including 78 in urine (24 prototypes and 54 metabolites), 26 in feces (19 prototypes and 7 metabolites), and 9 in plasma (5 prototypes and 4 metabolites). In other tissues, only a few compounds, including alkaloids and iridoids, were detected. CONCLUSION: This comprehensive investigation of the chemical and metabolic profiles of XRG-4 provides a scientific foundation for its quality control and administration of clinically-safe medication.