Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach

BACKGROUND: Xieriga-4 decoction (XRG-4) is a classic prescription Mongolian medicine that has potent diuretic and anti-inflammatory activities. However, its functional components remain unknown. PURPOSE: This study aimed to identify the chemical components in XRG-4 and its metabolome in vivo. METHOD...

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Autores principales: Ma, Yuanyuan, Ma, Ruiting, ZhiGui, Sa, QiLa, Zhao, Na, Wurigumala, Burentegusi, Guo, Zhigang, Tumenwuliji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683986/
https://www.ncbi.nlm.nih.gov/pubmed/36437832
http://dx.doi.org/10.1155/2022/8197364
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author Ma, Yuanyuan
Ma, Ruiting
ZhiGui,
Sa, QiLa
Zhao, Na
Wurigumala,
Burentegusi,
Guo, Zhigang
Tumenwuliji,
author_facet Ma, Yuanyuan
Ma, Ruiting
ZhiGui,
Sa, QiLa
Zhao, Na
Wurigumala,
Burentegusi,
Guo, Zhigang
Tumenwuliji,
author_sort Ma, Yuanyuan
collection PubMed
description BACKGROUND: Xieriga-4 decoction (XRG-4) is a classic prescription Mongolian medicine that has potent diuretic and anti-inflammatory activities. However, its functional components remain unknown. PURPOSE: This study aimed to identify the chemical components in XRG-4 and its metabolome in vivo. METHODS: An ultra-performance liquid chromatography coupled with a quadrupole time-of-flight tandem mass spectrometry based approach was proposed to systematically profile the chemicolome and metabolome of XRG-4. RESULT: A total of 106 constituents were identified in XRG-4. Eighty-nine components were identified in biological samples, including 78 in urine (24 prototypes and 54 metabolites), 26 in feces (19 prototypes and 7 metabolites), and 9 in plasma (5 prototypes and 4 metabolites). In other tissues, only a few compounds, including alkaloids and iridoids, were detected. CONCLUSION: This comprehensive investigation of the chemical and metabolic profiles of XRG-4 provides a scientific foundation for its quality control and administration of clinically-safe medication.
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spelling pubmed-96839862022-11-24 Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach Ma, Yuanyuan Ma, Ruiting ZhiGui, Sa, QiLa Zhao, Na Wurigumala, Burentegusi, Guo, Zhigang Tumenwuliji, Evid Based Complement Alternat Med Research Article BACKGROUND: Xieriga-4 decoction (XRG-4) is a classic prescription Mongolian medicine that has potent diuretic and anti-inflammatory activities. However, its functional components remain unknown. PURPOSE: This study aimed to identify the chemical components in XRG-4 and its metabolome in vivo. METHODS: An ultra-performance liquid chromatography coupled with a quadrupole time-of-flight tandem mass spectrometry based approach was proposed to systematically profile the chemicolome and metabolome of XRG-4. RESULT: A total of 106 constituents were identified in XRG-4. Eighty-nine components were identified in biological samples, including 78 in urine (24 prototypes and 54 metabolites), 26 in feces (19 prototypes and 7 metabolites), and 9 in plasma (5 prototypes and 4 metabolites). In other tissues, only a few compounds, including alkaloids and iridoids, were detected. CONCLUSION: This comprehensive investigation of the chemical and metabolic profiles of XRG-4 provides a scientific foundation for its quality control and administration of clinically-safe medication. Hindawi 2022-11-16 /pmc/articles/PMC9683986/ /pubmed/36437832 http://dx.doi.org/10.1155/2022/8197364 Text en Copyright © 2022 Yuanyuan Ma et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ma, Yuanyuan
Ma, Ruiting
ZhiGui,
Sa, QiLa
Zhao, Na
Wurigumala,
Burentegusi,
Guo, Zhigang
Tumenwuliji,
Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach
title Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach
title_full Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach
title_fullStr Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach
title_full_unstemmed Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach
title_short Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach
title_sort chemicolome and metabolome profiling of xieriga-4 decoction, a traditional mongolian medicine, using the uplc-qtof/ms approach
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683986/
https://www.ncbi.nlm.nih.gov/pubmed/36437832
http://dx.doi.org/10.1155/2022/8197364
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