ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma

Enhanced fatty acid synthesis is a hallmark of tumors, including glioblastoma. SREBF1/2 regulate the expression of enzymes involved in fatty acid and cholesterol synthesis. Yet, little is known about the precise mechanism regulating SREBP gene expression in glioblastoma. Here, we show that a novel i...

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Detalles Bibliográficos
Autores principales: Ferrarese, Roberto, Izzo, Annalisa, Andrieux, Geoffroy, Lagies, Simon, Bartmuss, Johanna Paulina, Masilamani, Anie Priscilla, Wasilenko, Alix, Osti, Daniela, Faletti, Stefania, Schulzki, Rana, Yuan, Shuai, Kling, Eva, Ribecco, Valentino, Heiland, Dieter Henrik, Tholen, Stefan, Prinz, Marco, Pelicci, Giuliana, Kammerer, Bernd, Boerries, Melanie, Carro, Maria Stella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684030/
https://www.ncbi.nlm.nih.gov/pubmed/36414381
http://dx.doi.org/10.26508/lsa.202201400

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