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AAV2-VEGF-B gene therapy failed to induce angiogenesis in ischemic porcine myocardium due to inflammatory responses

Therapeutic angiogenesis induced by gene therapy is a promising approach to treat patients suffering from severe coronary artery disease. In small experimental animals, adeno-associated viruses (AAVs) have shown good transduction efficacy and long-term transgene expression in heart muscle and other...

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Detalles Bibliográficos
Autores principales:	Korpela, Henna, Lampela, Jaakko, Airaksinen, Jonna, Järveläinen, Niko, Siimes, Satu, Valli, Kaisa, Nieminen, Tiina, Turunen, Minttu, Grönman, Maria, Saraste, Antti, Knuuti, Juhani, Hakulinen, Mikko, Poutiainen, Pekka, Kärjä, Vesa, Nurro, Jussi, Ylä-Herttuala, Seppo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684066/ https://www.ncbi.nlm.nih.gov/pubmed/35132204 http://dx.doi.org/10.1038/s41434-022-00322-9

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