Nuclear localization of alpha-synuclein affects the cognitive and motor behavior of mice by inducing DNA damage and abnormal cell cycle of hippocampal neurons

Nuclear accumulation of alpha-synuclein (α-syn) in neurons can promote neurotoxicity, which is considered the key factor in the pathogenesis of synucleinopathy. The damage to hippocampus neurons driven by α-syn pathology is also the potential cause of memory impairment in Parkinson’s disease (PD) pa...

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Detalles Bibliográficos
Autores principales: Pan, Yue, Zong, Qinglan, Li, Guoxiang, Wu, Zhengcun, Du, Tingfu, Huang, Zhangqiong, Zhang, Ying, Ma, Kaili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684191/
https://www.ncbi.nlm.nih.gov/pubmed/36438187
http://dx.doi.org/10.3389/fnmol.2022.1015881

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