Cargando…

Bim Deletion Reduces Functional Deficits Following Ischemic Stroke in Association with Modulation of Apoptosis and Inflammation

Cellular apoptosis is a key pathological mechanism contributing to neuronal death following ischemic stroke. The pro-apoptotic Bcl-2 family protein, Bim, is an important regulator of apoptosis. In this study we investigated the effect of Bim expression on post-stroke functional outcomes, brain injur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Glab, Jason A., Puthalakath, Hamsa, Zhang, Shenpeng R., Vinh, Antony, Drummond, Grant R., Sobey, Christopher G., De Silva, T. Michael, Kim, Hyun Ah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684233/ https://www.ncbi.nlm.nih.gov/pubmed/35149957 http://dx.doi.org/10.1007/s12017-022-08703-4

Ejemplares similares

Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells
por: Enders, Anselm, et al.
Publicado: (2003)

Vitamin D(3) Supplementation Reduces Subsequent Brain Injury and Inflammation Associated with Ischemic Stroke
por: Evans, Megan A., et al.
Publicado: (2018)

BH3-only proteins: the thorny end of the ER stress response
por: Glab, Jason A, et al.
Publicado: (2017)

Protection against brain injury after ischemic stroke by intravenous human amnion epithelial cells in combination with tissue plasminogen activator
por: Barreto-Arce, Liz J., et al.
Publicado: (2023)

Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3 Mimetics
por: Cragg, Mark S, et al.
Publicado: (2007)

IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice
por: Zhang, Shenpeng R., et al.
Publicado: (2019)

Sepsis: Inflammation Is a Necessary Evil
por: Nedeva, Christina, et al.
Publicado: (2019)

Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice
por: Doerflinger, Marcel, et al.
Publicado: (2016)

Nox1 Oxidase Suppresses Influenza A Virus-Induced Lung Inflammation and Oxidative Stress
por: Selemidis, Stavros, et al.
Publicado: (2013)

Phase I trial outcome of amnion cell therapy in patients with ischemic stroke (I-ACT)
por: Phan, Thanh G., et al.
Publicado: (2023)

Brain immune cell composition and functional outcome after cerebral ischemia: comparison of two mouse strains
por: Kim, Hyun Ah, et al.
Publicado: (2014)

Amnion epithelial cells – a novel therapy for ischemic stroke?
por: Evans, Megan A., et al.
Publicado: (2018)

Stimulation of β‐adrenoceptors up‐regulates cardiac expression of galectin‐3 and BIM through the Hippo signalling pathway
por: Zhao, Wei‐Bo, et al.
Publicado: (2019)

Corrigendum: Phase I trial outcome of amnion cell therapy in patients with ischemic stroke (I-ACT)
por: Phan, Thanh G., et al.
Publicado: (2023)

Nox2 Oxidase Activity Accounts for the Oxidative Stress and Vasomotor Dysfunction in Mouse Cerebral Arteries following Ischemic Stroke
por: De Silva, T. Michael, et al.
Publicado: (2011)

Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim
por: Marshall, B, et al.
Publicado: (2015)

Post-stroke inflammation and the potential efficacy of novel stem cell therapies: focus on amnion epithelial cells
por: Broughton, Brad R. S., et al.
Publicado: (2013)

Bim plays apoptosis offense
por: Powell, Kendall
Publicado: (2007)

Roles of Inflammation, Oxidative Stress, and Vascular Dysfunction in Hypertension
por: Dinh, Quynh N., et al.
Publicado: (2014)

The Vascular Consequences of Metabolic Syndrome: Rodent Models, Endothelial Dysfunction, and Current Therapies
por: Tran, Vivian, et al.
Publicado: (2020)

Association of constipation with increased risk of hypertension and cardiovascular events in elderly Australian patients
por: Judkins, Courtney P., et al.
Publicado: (2023)

Cell-specific mineralocorticoid receptors: future therapeutic targets for stroke?
por: Dinh, Quynh N., et al.
Publicado: (2016)

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress
por: Dinh, Quynh Nhu, et al.
Publicado: (2017)

Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA
por: Herold, M J, et al.
Publicado: (2014)

BIM-mediated apoptosis and oncogene addiction
por: Li, Yulin, et al.
Publicado: (2016)

Immune Mechanisms in Vascular Disease and Stroke
por: Toh, Ban-Hock, et al.
Publicado: (2014)

TLR4: the fall guy in sepsis?
por: Menassa, Joseph, et al.
Publicado: (2020)

Role of BIM Deletion Polymorphism and BIM Expression as Predictive Biomarkers to Maximize the Benefit of EGFR-TKI Treatment in EGFR-Positive NSCLC
por: Incharoen, Pimpin, et al.
Publicado: (2019)

Aldosterone and the mineralocorticoid receptor in the cerebral circulation and stroke
por: Dinh, Quynh N, et al.
Publicado: (2012)

MNT suppresses T cell apoptosis via BIM and is critical for T lymphomagenesis
por: Nguyen, Hai Vu, et al.
Publicado: (2023)

Over-Expression of DSCR1 Protects against Post-Ischemic Neuronal Injury
por: Brait, Vanessa H., et al.
Publicado: (2012)

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice
por: Herold, M J, et al.
Publicado: (2014)

Pre-ischemic exercise prevents inflammation and apoptosis by inhibiting MAPK pathway in ischemic stroke
por: Gao, Zhen-Kun, et al.
Publicado: (2022)

Implementation of Space Charge Forces in BimBim
por: Gottlob, Emmanuel
Publicado: (2017)

Sex hormones, intestinal inflammation, and the gut microbiome: Major influencers of the sexual dimorphisms in obesity
por: Brettle, Holly, et al.
Publicado: (2022)

Treadmill training improves neurological deficits and suppresses neuronal apoptosis in cerebral ischemic stroke rats
por: Cao, Li-Mei, et al.
Publicado: (2019)

Proteasome inhibition reduces plasma cell and antibody secretion, but not angiotensin II-induced hypertension
por: Figueiredo Galvao, Hericka Bruna, et al.
Publicado: (2023)

Bim and Bmf Synergize To Induce Apoptosis in Neisseria Gonorrhoeae Infection
por: Kepp, Oliver, et al.
Publicado: (2009)

Bim is a crucial regulator of apoptosis induced by Mycobacterium tuberculosis
por: Aguiló, N, et al.
Publicado: (2014)

Identification of Potential Biomarkers for Cancer Cachexia and Anti-Fn14 Therapy
por: Cao, Zhipeng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ptfbunogroets9r3t4jl0748t5