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Investigating transmission of SARS-CoV-2 using novel face mask sampling: a protocol for an observational prospective study of index cases and their contacts in a congregate setting

INTRODUCTION: This study aims to measure how transmission of SARS-CoV-2 occurs in communities and to identify conditions that lend to increased transmission focusing on congregate situations. We will measure SARS-CoV-2 in exhaled breath of asymptomatic and symptomatic persons using face mask samplin...

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Autores principales: Jaenisch, Thomas, Lamb, Molly M, Gallichotte, Emily N, Adams, Brian, Henry, Charles, Riess, Jeannine, van Sickle, Joni Triantis, Hawkins, Kellie L, Montague, Brian T, Coburn, Cody, Conners Bauer, Leisha, Kovarik, Jennifer, Hernandez, Mark T, Bronson, Amy, Graham, Lucy, James, Stephanie, Hanenberg, Stephanie, Kovacs, James, Spencer, John S, Zabel, Mark, Fox, Philip D, Pluss, Olivia, Windsor, William, Winstanley, Geoffrey, Olson, Daniel, Barer, Michael, Berman, Stephen, Ebel, Gregory, Chu, May
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684274/
https://www.ncbi.nlm.nih.gov/pubmed/36418127
http://dx.doi.org/10.1136/bmjopen-2022-061029
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author Jaenisch, Thomas
Lamb, Molly M
Gallichotte, Emily N
Adams, Brian
Henry, Charles
Riess, Jeannine
van Sickle, Joni Triantis
Hawkins, Kellie L
Montague, Brian T
Coburn, Cody
Conners Bauer, Leisha
Kovarik, Jennifer
Hernandez, Mark T
Bronson, Amy
Graham, Lucy
James, Stephanie
Hanenberg, Stephanie
Kovacs, James
Spencer, John S
Zabel, Mark
Fox, Philip D
Pluss, Olivia
Windsor, William
Winstanley, Geoffrey
Olson, Daniel
Barer, Michael
Berman, Stephen
Ebel, Gregory
Chu, May
author_facet Jaenisch, Thomas
Lamb, Molly M
Gallichotte, Emily N
Adams, Brian
Henry, Charles
Riess, Jeannine
van Sickle, Joni Triantis
Hawkins, Kellie L
Montague, Brian T
Coburn, Cody
Conners Bauer, Leisha
Kovarik, Jennifer
Hernandez, Mark T
Bronson, Amy
Graham, Lucy
James, Stephanie
Hanenberg, Stephanie
Kovacs, James
Spencer, John S
Zabel, Mark
Fox, Philip D
Pluss, Olivia
Windsor, William
Winstanley, Geoffrey
Olson, Daniel
Barer, Michael
Berman, Stephen
Ebel, Gregory
Chu, May
author_sort Jaenisch, Thomas
collection PubMed
description INTRODUCTION: This study aims to measure how transmission of SARS-CoV-2 occurs in communities and to identify conditions that lend to increased transmission focusing on congregate situations. We will measure SARS-CoV-2 in exhaled breath of asymptomatic and symptomatic persons using face mask sampling—a non-invasive method for SARS-CoV-2 detection in exhaled air. We aim to detect transmission clusters and identify risk factors for SARS-CoV-2 transmission in presymptomatic, asymptomatic and symptomatic individuals. METHODS AND ANALYSIS: In this observational prospective study with daily follow-up, index cases and their respective contacts are identified at each participating institution. Contact definitions are based on Centers for Disease Control and Prevention and local health department guidelines. Participants will wear masks with polyvinyl alcohol test strips adhered to the inside for 2 hours daily. The strips are applied to all masks used over at least 7 days. In addition, self-administered nasal swabs and (optional) finger prick blood samples are performed by participants. Samples are tested by standard PCR protocols and by novel antigen tests. ETHICS AND DISSEMINATION: This study was approved by the Colorado Multiple Institutional Review Board and the WHO Ethics Review Committee. From the data generated, we will analyse transmission clusters and risk factors for transmission of SARS-CoV-2 in congregate settings. The kinetics of asymptomatic transmission and the evaluation of non-invasive tools for detection of transmissibility are of crucial importance for the development of more targeted control interventions—and ultimately to assist with keeping congregate settings open that are essential for our social fabric. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov (#NCT05145803).
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spelling pubmed-96842742022-11-25 Investigating transmission of SARS-CoV-2 using novel face mask sampling: a protocol for an observational prospective study of index cases and their contacts in a congregate setting Jaenisch, Thomas Lamb, Molly M Gallichotte, Emily N Adams, Brian Henry, Charles Riess, Jeannine van Sickle, Joni Triantis Hawkins, Kellie L Montague, Brian T Coburn, Cody Conners Bauer, Leisha Kovarik, Jennifer Hernandez, Mark T Bronson, Amy Graham, Lucy James, Stephanie Hanenberg, Stephanie Kovacs, James Spencer, John S Zabel, Mark Fox, Philip D Pluss, Olivia Windsor, William Winstanley, Geoffrey Olson, Daniel Barer, Michael Berman, Stephen Ebel, Gregory Chu, May BMJ Open Infectious Diseases INTRODUCTION: This study aims to measure how transmission of SARS-CoV-2 occurs in communities and to identify conditions that lend to increased transmission focusing on congregate situations. We will measure SARS-CoV-2 in exhaled breath of asymptomatic and symptomatic persons using face mask sampling—a non-invasive method for SARS-CoV-2 detection in exhaled air. We aim to detect transmission clusters and identify risk factors for SARS-CoV-2 transmission in presymptomatic, asymptomatic and symptomatic individuals. METHODS AND ANALYSIS: In this observational prospective study with daily follow-up, index cases and their respective contacts are identified at each participating institution. Contact definitions are based on Centers for Disease Control and Prevention and local health department guidelines. Participants will wear masks with polyvinyl alcohol test strips adhered to the inside for 2 hours daily. The strips are applied to all masks used over at least 7 days. In addition, self-administered nasal swabs and (optional) finger prick blood samples are performed by participants. Samples are tested by standard PCR protocols and by novel antigen tests. ETHICS AND DISSEMINATION: This study was approved by the Colorado Multiple Institutional Review Board and the WHO Ethics Review Committee. From the data generated, we will analyse transmission clusters and risk factors for transmission of SARS-CoV-2 in congregate settings. The kinetics of asymptomatic transmission and the evaluation of non-invasive tools for detection of transmissibility are of crucial importance for the development of more targeted control interventions—and ultimately to assist with keeping congregate settings open that are essential for our social fabric. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov (#NCT05145803). BMJ Publishing Group 2022-11-23 /pmc/articles/PMC9684274/ /pubmed/36418127 http://dx.doi.org/10.1136/bmjopen-2022-061029 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Infectious Diseases
Jaenisch, Thomas
Lamb, Molly M
Gallichotte, Emily N
Adams, Brian
Henry, Charles
Riess, Jeannine
van Sickle, Joni Triantis
Hawkins, Kellie L
Montague, Brian T
Coburn, Cody
Conners Bauer, Leisha
Kovarik, Jennifer
Hernandez, Mark T
Bronson, Amy
Graham, Lucy
James, Stephanie
Hanenberg, Stephanie
Kovacs, James
Spencer, John S
Zabel, Mark
Fox, Philip D
Pluss, Olivia
Windsor, William
Winstanley, Geoffrey
Olson, Daniel
Barer, Michael
Berman, Stephen
Ebel, Gregory
Chu, May
Investigating transmission of SARS-CoV-2 using novel face mask sampling: a protocol for an observational prospective study of index cases and their contacts in a congregate setting
title Investigating transmission of SARS-CoV-2 using novel face mask sampling: a protocol for an observational prospective study of index cases and their contacts in a congregate setting
title_full Investigating transmission of SARS-CoV-2 using novel face mask sampling: a protocol for an observational prospective study of index cases and their contacts in a congregate setting
title_fullStr Investigating transmission of SARS-CoV-2 using novel face mask sampling: a protocol for an observational prospective study of index cases and their contacts in a congregate setting
title_full_unstemmed Investigating transmission of SARS-CoV-2 using novel face mask sampling: a protocol for an observational prospective study of index cases and their contacts in a congregate setting
title_short Investigating transmission of SARS-CoV-2 using novel face mask sampling: a protocol for an observational prospective study of index cases and their contacts in a congregate setting
title_sort investigating transmission of sars-cov-2 using novel face mask sampling: a protocol for an observational prospective study of index cases and their contacts in a congregate setting
topic Infectious Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684274/
https://www.ncbi.nlm.nih.gov/pubmed/36418127
http://dx.doi.org/10.1136/bmjopen-2022-061029
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