RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway

mRNA level is controlled by factors that mediate both mRNA synthesis and decay, including the 5’ to 3’ exonuclease Xrn1. Here we show that nucleocytoplasmic shuttling of several yeast mRNA decay factors plays a key role in determining both mRNA synthesis and decay. Shuttling is regulated by RNA-cont...

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Detalles Bibliográficos
Autores principales: Chattopadhyay, Shiladitya, Garcia-Martinez, Jose, Haimovich, Gal, Fischer, Jonathan, Khwaja, Aya, Barkai, Oren, Chuartzman, Silvia Gabriela, Schuldiner, Maya, Elran, Ron, Rosenberg, Miriam I., Urim, Shira, Deshmukh, Shubham, Bohnsack, Katherine E., Bohnsack, Markus T., Perez-Ortin, Jose E., Choder, Mordechai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684461/
https://www.ncbi.nlm.nih.gov/pubmed/36418294
http://dx.doi.org/10.1038/s41467-022-34417-z

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