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W(18)O(49)@EP nanoparticles improve the anti-tumor effect of radiotherapy and photodynamic therapy by avoiding the limitation of hypoxia
Insufficient oxygen supply at the tumor site and hypoxia caused during tumor treatment lead to a poor therapeutic effect and poor prognosis. Therefore, effectively overcoming the problem of hypoxia in tumors and avoiding hypoxia that compromises the efficacy of the treatment could improve the anti-t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684464/ https://www.ncbi.nlm.nih.gov/pubmed/36440440 http://dx.doi.org/10.3389/fbioe.2022.1060467 |
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author | Wang, Jianquan Hao, Lingyun Li, Xinhua Liu, Sen |
author_facet | Wang, Jianquan Hao, Lingyun Li, Xinhua Liu, Sen |
author_sort | Wang, Jianquan |
collection | PubMed |
description | Insufficient oxygen supply at the tumor site and hypoxia caused during tumor treatment lead to a poor therapeutic effect and poor prognosis. Therefore, effectively overcoming the problem of hypoxia in tumors and avoiding hypoxia that compromises the efficacy of the treatment could improve the anti-tumor therapeutic effect. Thus, this study reports the ability of W(18)O(49)@EP nanoparticles to release reactive oxygen species (ROS) during the combined tumor radiotherapy (RT) and photodynamic therapy (PDT). The release of ROS by the nanoparticles during near infrared light (NIR) irradiation was demonstrated by in vitro and in vivo experiments, realizing an effective PDT without inducing hypoxia. Indeed, the ROS did not derive from the oxygen in the tumor microenvironment but they were released by the nanoparticles. Thus, ROS could improve the therapeutic effect of RT avoiding the problem of hypoxia after RT. Hence, W(18)O(49)@EP nanoparticles greatly improved the anti-tumor effect due to their effectiveness despite the insufficient oxygen supply and hypoxia caused by traditional RT and PDT. |
format | Online Article Text |
id | pubmed-9684464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96844642022-11-25 W(18)O(49)@EP nanoparticles improve the anti-tumor effect of radiotherapy and photodynamic therapy by avoiding the limitation of hypoxia Wang, Jianquan Hao, Lingyun Li, Xinhua Liu, Sen Front Bioeng Biotechnol Bioengineering and Biotechnology Insufficient oxygen supply at the tumor site and hypoxia caused during tumor treatment lead to a poor therapeutic effect and poor prognosis. Therefore, effectively overcoming the problem of hypoxia in tumors and avoiding hypoxia that compromises the efficacy of the treatment could improve the anti-tumor therapeutic effect. Thus, this study reports the ability of W(18)O(49)@EP nanoparticles to release reactive oxygen species (ROS) during the combined tumor radiotherapy (RT) and photodynamic therapy (PDT). The release of ROS by the nanoparticles during near infrared light (NIR) irradiation was demonstrated by in vitro and in vivo experiments, realizing an effective PDT without inducing hypoxia. Indeed, the ROS did not derive from the oxygen in the tumor microenvironment but they were released by the nanoparticles. Thus, ROS could improve the therapeutic effect of RT avoiding the problem of hypoxia after RT. Hence, W(18)O(49)@EP nanoparticles greatly improved the anti-tumor effect due to their effectiveness despite the insufficient oxygen supply and hypoxia caused by traditional RT and PDT. Frontiers Media S.A. 2022-11-10 /pmc/articles/PMC9684464/ /pubmed/36440440 http://dx.doi.org/10.3389/fbioe.2022.1060467 Text en Copyright © 2022 Wang, Hao, Li and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Wang, Jianquan Hao, Lingyun Li, Xinhua Liu, Sen W(18)O(49)@EP nanoparticles improve the anti-tumor effect of radiotherapy and photodynamic therapy by avoiding the limitation of hypoxia |
title | W(18)O(49)@EP nanoparticles improve the anti-tumor effect of radiotherapy and photodynamic therapy by avoiding the limitation of hypoxia |
title_full | W(18)O(49)@EP nanoparticles improve the anti-tumor effect of radiotherapy and photodynamic therapy by avoiding the limitation of hypoxia |
title_fullStr | W(18)O(49)@EP nanoparticles improve the anti-tumor effect of radiotherapy and photodynamic therapy by avoiding the limitation of hypoxia |
title_full_unstemmed | W(18)O(49)@EP nanoparticles improve the anti-tumor effect of radiotherapy and photodynamic therapy by avoiding the limitation of hypoxia |
title_short | W(18)O(49)@EP nanoparticles improve the anti-tumor effect of radiotherapy and photodynamic therapy by avoiding the limitation of hypoxia |
title_sort | w(18)o(49)@ep nanoparticles improve the anti-tumor effect of radiotherapy and photodynamic therapy by avoiding the limitation of hypoxia |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684464/ https://www.ncbi.nlm.nih.gov/pubmed/36440440 http://dx.doi.org/10.3389/fbioe.2022.1060467 |
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