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Management of pregnant patients with pulmonary arterial hypertension
Pregnant individuals with pulmonary arterial hypertension (PAH) have significantly high risks of maternal and perinatal mortality. Profound changes in plasma volume, cardiac output and systemic vascular resistance can all increase the strain being placed on the right ventricle, leading to heart fail...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684470/ https://www.ncbi.nlm.nih.gov/pubmed/36440029 http://dx.doi.org/10.3389/fcvm.2022.1029057 |
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author | Zhang, Xiao Huangfu, Zhao |
author_facet | Zhang, Xiao Huangfu, Zhao |
author_sort | Zhang, Xiao |
collection | PubMed |
description | Pregnant individuals with pulmonary arterial hypertension (PAH) have significantly high risks of maternal and perinatal mortality. Profound changes in plasma volume, cardiac output and systemic vascular resistance can all increase the strain being placed on the right ventricle, leading to heart failure and cardiovascular collapse. Given the complex network of opposing physiological changes, strict contraception and reduction of hemodynamic fluctuations during pregnancy are important methods of minimizing the risk of maternal mortality and improving the outcomes following pregnancy. In this review, we discuss the recent research progress into pre-conception management and the various therapeutic strategies for pregnant individuals with PAH. |
format | Online Article Text |
id | pubmed-9684470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96844702022-11-25 Management of pregnant patients with pulmonary arterial hypertension Zhang, Xiao Huangfu, Zhao Front Cardiovasc Med Cardiovascular Medicine Pregnant individuals with pulmonary arterial hypertension (PAH) have significantly high risks of maternal and perinatal mortality. Profound changes in plasma volume, cardiac output and systemic vascular resistance can all increase the strain being placed on the right ventricle, leading to heart failure and cardiovascular collapse. Given the complex network of opposing physiological changes, strict contraception and reduction of hemodynamic fluctuations during pregnancy are important methods of minimizing the risk of maternal mortality and improving the outcomes following pregnancy. In this review, we discuss the recent research progress into pre-conception management and the various therapeutic strategies for pregnant individuals with PAH. Frontiers Media S.A. 2022-11-10 /pmc/articles/PMC9684470/ /pubmed/36440029 http://dx.doi.org/10.3389/fcvm.2022.1029057 Text en Copyright © 2022 Zhang and Huangfu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Zhang, Xiao Huangfu, Zhao Management of pregnant patients with pulmonary arterial hypertension |
title | Management of pregnant patients with pulmonary arterial hypertension |
title_full | Management of pregnant patients with pulmonary arterial hypertension |
title_fullStr | Management of pregnant patients with pulmonary arterial hypertension |
title_full_unstemmed | Management of pregnant patients with pulmonary arterial hypertension |
title_short | Management of pregnant patients with pulmonary arterial hypertension |
title_sort | management of pregnant patients with pulmonary arterial hypertension |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684470/ https://www.ncbi.nlm.nih.gov/pubmed/36440029 http://dx.doi.org/10.3389/fcvm.2022.1029057 |
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