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Compact zinc finger base editors that edit mitochondrial or nuclear DNA in vitro and in vivo

DddA-derived cytosine base editors (DdCBEs) use programmable DNA-binding TALE repeat arrays, rather than CRISPR proteins, a split double-stranded DNA cytidine deaminase (DddA), and a uracil glycosylase inhibitor to mediate C•G-to-T•A editing in nuclear and organelle DNA. Here we report the developme...

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Detalles Bibliográficos
Autores principales:	Willis, Julian C. W., Silva-Pinheiro, Pedro, Widdup, Lily, Minczuk, Michal, Liu, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684478/ https://www.ncbi.nlm.nih.gov/pubmed/36418298 http://dx.doi.org/10.1038/s41467-022-34784-7

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