A non-coding GWAS variant impacts anthracycline-induced cardiotoxic phenotypes in human iPSC-derived cardiomyocytes

Anthracyclines, widely used to treat breast cancer, have the potential for cardiotoxicity. We have previously identified and validated a germline single nucleotide polymorphism, rs28714259, associated with an increased risk of anthracycline-induced heart failure. We now provide insights into the mec...

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Detalles Bibliográficos
Autores principales: Wu, Xi, Shen, Fei, Jiang, Guanglong, Xue, Gloria, Philips, Santosh, Gardner, Laura, Cunningham, Geneva, Bales, Casey, Cantor, Erica, Schneider, Bryan Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684507/
https://www.ncbi.nlm.nih.gov/pubmed/36418322
http://dx.doi.org/10.1038/s41467-022-34917-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684507/
https://www.ncbi.nlm.nih.gov/pubmed/36418322
http://dx.doi.org/10.1038/s41467-022-34917-y

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