Reversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies

The association between loss of BRCA1/2 and a homologous recombination deficiency phenotype is lineage dependent. In BRCA-associated cancers such as breast, ovarian, pancreas and prostate, this phenotype confers sensitivity to PARP inhibitors and platinum-therapies. Somatic reversion mutations resto...

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Detalles Bibliográficos
Autores principales: Murciano-Goroff, Yonina R., Schram, Alison M., Rosen, Ezra Y., Won, Helen, Gong, Yixiao, Noronha, Anne Marie, Janjigian, Yelena Y., Stadler, Zsofia K., Chang, Jason C., Yang, Soo-Ryum, Mandelker, Diana, Offit, Kenneth, Berger, Michael F., Donoghue, Mark T. A., Bandlamudi, Chaitanya, Drilon, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684575/
https://www.ncbi.nlm.nih.gov/pubmed/36418296
http://dx.doi.org/10.1038/s41467-022-34109-8

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