Cargando…
Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity
Human immunodeficiency virus (HIV) infection might have effects on both the human bacteriome and mycobiome. Although many studies have focused on alteration of the bacteriome in HIV infection, only a handful of studies have also characterized the composition of the mycobiome in HIV-infected individu...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684632/ https://www.ncbi.nlm.nih.gov/pubmed/36439143 http://dx.doi.org/10.3389/fimmu.2022.1015775 |
_version_ | 1784835332536008704 |
---|---|
author | Li, Shuang Yang, Xiaodong Moog, Christiane Wu, Hao Su, Bin Zhang, Tong |
author_facet | Li, Shuang Yang, Xiaodong Moog, Christiane Wu, Hao Su, Bin Zhang, Tong |
author_sort | Li, Shuang |
collection | PubMed |
description | Human immunodeficiency virus (HIV) infection might have effects on both the human bacteriome and mycobiome. Although many studies have focused on alteration of the bacteriome in HIV infection, only a handful of studies have also characterized the composition of the mycobiome in HIV-infected individuals. Studies have shown that compromised immunity in HIV infection might contribute to the development of opportunistic fungal infections. Despite effective antiretroviral therapy (ART), opportunistic fungal infections continue to be a major cause of HIV-related mortality. Human immune responses are known to play a critical role in controlling fungal infections. However, the effect of HIV infection on innate and adaptive antifungal immunity remains unclear. Here, we review recent advances in understanding of the fungal microbiota composition and common fungal diseases in the setting of HIV. Moreover, we discuss innate and adaptive antifungal immunity in HIV infection. |
format | Online Article Text |
id | pubmed-9684632 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96846322022-11-25 Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity Li, Shuang Yang, Xiaodong Moog, Christiane Wu, Hao Su, Bin Zhang, Tong Front Immunol Immunology Human immunodeficiency virus (HIV) infection might have effects on both the human bacteriome and mycobiome. Although many studies have focused on alteration of the bacteriome in HIV infection, only a handful of studies have also characterized the composition of the mycobiome in HIV-infected individuals. Studies have shown that compromised immunity in HIV infection might contribute to the development of opportunistic fungal infections. Despite effective antiretroviral therapy (ART), opportunistic fungal infections continue to be a major cause of HIV-related mortality. Human immune responses are known to play a critical role in controlling fungal infections. However, the effect of HIV infection on innate and adaptive antifungal immunity remains unclear. Here, we review recent advances in understanding of the fungal microbiota composition and common fungal diseases in the setting of HIV. Moreover, we discuss innate and adaptive antifungal immunity in HIV infection. Frontiers Media S.A. 2022-11-10 /pmc/articles/PMC9684632/ /pubmed/36439143 http://dx.doi.org/10.3389/fimmu.2022.1015775 Text en Copyright © 2022 Li, Yang, Moog, Wu, Su and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Li, Shuang Yang, Xiaodong Moog, Christiane Wu, Hao Su, Bin Zhang, Tong Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity |
title | Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity |
title_full | Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity |
title_fullStr | Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity |
title_full_unstemmed | Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity |
title_short | Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity |
title_sort | neglected mycobiome in hiv infection: alterations, common fungal diseases and antifungal immunity |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684632/ https://www.ncbi.nlm.nih.gov/pubmed/36439143 http://dx.doi.org/10.3389/fimmu.2022.1015775 |
work_keys_str_mv | AT lishuang neglectedmycobiomeinhivinfectionalterationscommonfungaldiseasesandantifungalimmunity AT yangxiaodong neglectedmycobiomeinhivinfectionalterationscommonfungaldiseasesandantifungalimmunity AT moogchristiane neglectedmycobiomeinhivinfectionalterationscommonfungaldiseasesandantifungalimmunity AT wuhao neglectedmycobiomeinhivinfectionalterationscommonfungaldiseasesandantifungalimmunity AT subin neglectedmycobiomeinhivinfectionalterationscommonfungaldiseasesandantifungalimmunity AT zhangtong neglectedmycobiomeinhivinfectionalterationscommonfungaldiseasesandantifungalimmunity |