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Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity

Human immunodeficiency virus (HIV) infection might have effects on both the human bacteriome and mycobiome. Although many studies have focused on alteration of the bacteriome in HIV infection, only a handful of studies have also characterized the composition of the mycobiome in HIV-infected individu...

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Autores principales: Li, Shuang, Yang, Xiaodong, Moog, Christiane, Wu, Hao, Su, Bin, Zhang, Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684632/
https://www.ncbi.nlm.nih.gov/pubmed/36439143
http://dx.doi.org/10.3389/fimmu.2022.1015775
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author Li, Shuang
Yang, Xiaodong
Moog, Christiane
Wu, Hao
Su, Bin
Zhang, Tong
author_facet Li, Shuang
Yang, Xiaodong
Moog, Christiane
Wu, Hao
Su, Bin
Zhang, Tong
author_sort Li, Shuang
collection PubMed
description Human immunodeficiency virus (HIV) infection might have effects on both the human bacteriome and mycobiome. Although many studies have focused on alteration of the bacteriome in HIV infection, only a handful of studies have also characterized the composition of the mycobiome in HIV-infected individuals. Studies have shown that compromised immunity in HIV infection might contribute to the development of opportunistic fungal infections. Despite effective antiretroviral therapy (ART), opportunistic fungal infections continue to be a major cause of HIV-related mortality. Human immune responses are known to play a critical role in controlling fungal infections. However, the effect of HIV infection on innate and adaptive antifungal immunity remains unclear. Here, we review recent advances in understanding of the fungal microbiota composition and common fungal diseases in the setting of HIV. Moreover, we discuss innate and adaptive antifungal immunity in HIV infection.
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spelling pubmed-96846322022-11-25 Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity Li, Shuang Yang, Xiaodong Moog, Christiane Wu, Hao Su, Bin Zhang, Tong Front Immunol Immunology Human immunodeficiency virus (HIV) infection might have effects on both the human bacteriome and mycobiome. Although many studies have focused on alteration of the bacteriome in HIV infection, only a handful of studies have also characterized the composition of the mycobiome in HIV-infected individuals. Studies have shown that compromised immunity in HIV infection might contribute to the development of opportunistic fungal infections. Despite effective antiretroviral therapy (ART), opportunistic fungal infections continue to be a major cause of HIV-related mortality. Human immune responses are known to play a critical role in controlling fungal infections. However, the effect of HIV infection on innate and adaptive antifungal immunity remains unclear. Here, we review recent advances in understanding of the fungal microbiota composition and common fungal diseases in the setting of HIV. Moreover, we discuss innate and adaptive antifungal immunity in HIV infection. Frontiers Media S.A. 2022-11-10 /pmc/articles/PMC9684632/ /pubmed/36439143 http://dx.doi.org/10.3389/fimmu.2022.1015775 Text en Copyright © 2022 Li, Yang, Moog, Wu, Su and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Li, Shuang
Yang, Xiaodong
Moog, Christiane
Wu, Hao
Su, Bin
Zhang, Tong
Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity
title Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity
title_full Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity
title_fullStr Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity
title_full_unstemmed Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity
title_short Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity
title_sort neglected mycobiome in hiv infection: alterations, common fungal diseases and antifungal immunity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684632/
https://www.ncbi.nlm.nih.gov/pubmed/36439143
http://dx.doi.org/10.3389/fimmu.2022.1015775
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