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Difference in aqueous concentration and vitreous mass of cytokines in high myopias with and without choroidal neovascularization

PURPOSE: To investigate and compare the aqueous humor (AH) concentration and vitreous mass of cytokines in high myopias (HM) with and without myopic choroidal neovascularization (mCNV). And the correlations between cytokines and the size of CNVs on optical coherence tomography angiography (OCTA) ima...

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Autores principales: Zhang, Shian, Mao, Jianbo, Chen, Nuo, Fang, Yuyan, Chen, Yijing, Zheng, Zicheng, Chen, Yiqi, Shen, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684635/
https://www.ncbi.nlm.nih.gov/pubmed/36438065
http://dx.doi.org/10.3389/fmed.2022.1029425
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author Zhang, Shian
Mao, Jianbo
Chen, Nuo
Fang, Yuyan
Chen, Yijing
Zheng, Zicheng
Chen, Yiqi
Shen, Lijun
author_facet Zhang, Shian
Mao, Jianbo
Chen, Nuo
Fang, Yuyan
Chen, Yijing
Zheng, Zicheng
Chen, Yiqi
Shen, Lijun
author_sort Zhang, Shian
collection PubMed
description PURPOSE: To investigate and compare the aqueous humor (AH) concentration and vitreous mass of cytokines in high myopias (HM) with and without myopic choroidal neovascularization (mCNV). And the correlations between cytokines and the size of CNVs on optical coherence tomography angiography (OCTA) images were also be analyzed. METHODS: This observational study included 56 highly myopic eyes with and without CNV and 57 control eyes with cataracts. AH samples were obtained prior to the intravitreal injection of anti-VEGF and cataract surgery. This study measured multiple inflammatory cytokines including VEGF, interleukin (IL)-6, IL-8, IL-10, interferon-inducible protein-10 (IP-10), and monocyte chemotactic protein-1 (MCP-1) by multiplex bead assay. AH cytokine level, axial length, and vitreous volume were used to calculate the vitreous mass of cytokines. RESULTS: The vitreous mass of VEGF in eyes with mCNV was significantly higher than that in control group. However, the difference in AH concentration of VEGF between high myopias with mCNV was not observed. Inflammatory cytokines were upregulated (IL-6, IL-10, and MCP-1) in highly myopic eyes both with and without mCNV (all P<0.05). There was also a significant difference in the vitreous mass of IL-8 and IP-10 among all three groups (P<0.05). CONCLUSION: We confirmed the secretion of VEGF increased in eyes with mCNV from a new perspective. The development of both HM and mCNV were related to inflammatory cytokines and the upregulation of inflammatory cytokines may precede upregulation of VEGF. The vitreous mass might be tried as a more reliable potential biomarker in eyes with longer axial length.
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spelling pubmed-96846352022-11-25 Difference in aqueous concentration and vitreous mass of cytokines in high myopias with and without choroidal neovascularization Zhang, Shian Mao, Jianbo Chen, Nuo Fang, Yuyan Chen, Yijing Zheng, Zicheng Chen, Yiqi Shen, Lijun Front Med (Lausanne) Medicine PURPOSE: To investigate and compare the aqueous humor (AH) concentration and vitreous mass of cytokines in high myopias (HM) with and without myopic choroidal neovascularization (mCNV). And the correlations between cytokines and the size of CNVs on optical coherence tomography angiography (OCTA) images were also be analyzed. METHODS: This observational study included 56 highly myopic eyes with and without CNV and 57 control eyes with cataracts. AH samples were obtained prior to the intravitreal injection of anti-VEGF and cataract surgery. This study measured multiple inflammatory cytokines including VEGF, interleukin (IL)-6, IL-8, IL-10, interferon-inducible protein-10 (IP-10), and monocyte chemotactic protein-1 (MCP-1) by multiplex bead assay. AH cytokine level, axial length, and vitreous volume were used to calculate the vitreous mass of cytokines. RESULTS: The vitreous mass of VEGF in eyes with mCNV was significantly higher than that in control group. However, the difference in AH concentration of VEGF between high myopias with mCNV was not observed. Inflammatory cytokines were upregulated (IL-6, IL-10, and MCP-1) in highly myopic eyes both with and without mCNV (all P<0.05). There was also a significant difference in the vitreous mass of IL-8 and IP-10 among all three groups (P<0.05). CONCLUSION: We confirmed the secretion of VEGF increased in eyes with mCNV from a new perspective. The development of both HM and mCNV were related to inflammatory cytokines and the upregulation of inflammatory cytokines may precede upregulation of VEGF. The vitreous mass might be tried as a more reliable potential biomarker in eyes with longer axial length. Frontiers Media S.A. 2022-11-10 /pmc/articles/PMC9684635/ /pubmed/36438065 http://dx.doi.org/10.3389/fmed.2022.1029425 Text en Copyright © 2022 Zhang, Mao, Chen, Fang, Chen, Zheng, Chen and Shen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Zhang, Shian
Mao, Jianbo
Chen, Nuo
Fang, Yuyan
Chen, Yijing
Zheng, Zicheng
Chen, Yiqi
Shen, Lijun
Difference in aqueous concentration and vitreous mass of cytokines in high myopias with and without choroidal neovascularization
title Difference in aqueous concentration and vitreous mass of cytokines in high myopias with and without choroidal neovascularization
title_full Difference in aqueous concentration and vitreous mass of cytokines in high myopias with and without choroidal neovascularization
title_fullStr Difference in aqueous concentration and vitreous mass of cytokines in high myopias with and without choroidal neovascularization
title_full_unstemmed Difference in aqueous concentration and vitreous mass of cytokines in high myopias with and without choroidal neovascularization
title_short Difference in aqueous concentration and vitreous mass of cytokines in high myopias with and without choroidal neovascularization
title_sort difference in aqueous concentration and vitreous mass of cytokines in high myopias with and without choroidal neovascularization
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684635/
https://www.ncbi.nlm.nih.gov/pubmed/36438065
http://dx.doi.org/10.3389/fmed.2022.1029425
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