Non-coding RNAs: The link between maternal malnutrition and offspring metabolism

Early life nutrition is associated with the development and metabolism in later life, which is known as the Developmental Origin of Health and Diseases (DOHaD). Epigenetics have been proposed as an important explanation for this link between early life malnutrition and long-term diseases. Non-coding...

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Autores principales: Zeng, Yuan, Wu, Yifan, Zhang, Qian, Xiao, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Nutrition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684648/
https://www.ncbi.nlm.nih.gov/pubmed/36438765
http://dx.doi.org/10.3389/fnut.2022.1022784
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author Zeng, Yuan
Wu, Yifan
Zhang, Qian
Xiao, Xinhua
author_facet Zeng, Yuan
Wu, Yifan
Zhang, Qian
Xiao, Xinhua
author_sort Zeng, Yuan
collection PubMed
description Early life nutrition is associated with the development and metabolism in later life, which is known as the Developmental Origin of Health and Diseases (DOHaD). Epigenetics have been proposed as an important explanation for this link between early life malnutrition and long-term diseases. Non-coding RNAs (ncRNAs) may play a role in this epigenetic programming. The expression of ncRNAs (such as long non-coding RNA H19, microRNA-122, and circular RNA-SETD2) was significantly altered in specific tissues of offspring exposed to maternal malnutrition. Changes in these downstream targets of ncRNAs lead to abnormal development and metabolism. This review aims to summarize the existing knowledge on ncRNAs linking the maternal nutrition condition and offspring metabolic diseases, such as obesity, type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD).
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spelling pubmed-96846482022-11-25 Non-coding RNAs: The link between maternal malnutrition and offspring metabolism Zeng, Yuan Wu, Yifan Zhang, Qian Xiao, Xinhua Front Nutr Nutrition Early life nutrition is associated with the development and metabolism in later life, which is known as the Developmental Origin of Health and Diseases (DOHaD). Epigenetics have been proposed as an important explanation for this link between early life malnutrition and long-term diseases. Non-coding RNAs (ncRNAs) may play a role in this epigenetic programming. The expression of ncRNAs (such as long non-coding RNA H19, microRNA-122, and circular RNA-SETD2) was significantly altered in specific tissues of offspring exposed to maternal malnutrition. Changes in these downstream targets of ncRNAs lead to abnormal development and metabolism. This review aims to summarize the existing knowledge on ncRNAs linking the maternal nutrition condition and offspring metabolic diseases, such as obesity, type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). Frontiers Media S.A. 2022-11-10 /pmc/articles/PMC9684648/ /pubmed/36438765 http://dx.doi.org/10.3389/fnut.2022.1022784 Text en Copyright © 2022 Zeng, Wu, Zhang and Xiao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Zeng, Yuan
Wu, Yifan
Zhang, Qian
Xiao, Xinhua
Non-coding RNAs: The link between maternal malnutrition and offspring metabolism
title Non-coding RNAs: The link between maternal malnutrition and offspring metabolism
title_full Non-coding RNAs: The link between maternal malnutrition and offspring metabolism
title_fullStr Non-coding RNAs: The link between maternal malnutrition and offspring metabolism
title_full_unstemmed Non-coding RNAs: The link between maternal malnutrition and offspring metabolism
title_short Non-coding RNAs: The link between maternal malnutrition and offspring metabolism
title_sort non-coding rnas: the link between maternal malnutrition and offspring metabolism
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684648/
https://www.ncbi.nlm.nih.gov/pubmed/36438765
http://dx.doi.org/10.3389/fnut.2022.1022784
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AT xiaoxinhua noncodingrnasthelinkbetweenmaternalmalnutritionandoffspringmetabolism

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