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Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy

Cancer is a disease that induces many local and systemic changes in immunity. The difficult nature of ovarian cancer stems from the lack of characteristic symptoms that contributes to a delayed diagnosis and treatment. Despite the enormous progress in immunotherapy, its efficacy remains limited. The...

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Autores principales: Rajtak, Alicja, Ostrowska-Leśko, Marta, Żak, Klaudia, Tarkowski, Rafał, Kotarski, Jan, Okła, Karolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684707/
https://www.ncbi.nlm.nih.gov/pubmed/36439144
http://dx.doi.org/10.3389/fimmu.2022.1018256
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author Rajtak, Alicja
Ostrowska-Leśko, Marta
Żak, Klaudia
Tarkowski, Rafał
Kotarski, Jan
Okła, Karolina
author_facet Rajtak, Alicja
Ostrowska-Leśko, Marta
Żak, Klaudia
Tarkowski, Rafał
Kotarski, Jan
Okła, Karolina
author_sort Rajtak, Alicja
collection PubMed
description Cancer is a disease that induces many local and systemic changes in immunity. The difficult nature of ovarian cancer stems from the lack of characteristic symptoms that contributes to a delayed diagnosis and treatment. Despite the enormous progress in immunotherapy, its efficacy remains limited. The heterogeneity of tumors, lack of diagnostic biomarkers, and complex immune landscape are the main challenges in the treatment of ovarian cancer. Integrative approaches that combine the tumor microenvironment – local immunity – together with periphery – systemic immunity – are urgently needed to improve the understanding of the disease and the efficacy of treatment. In fact, multiparametric analyses are poised to improve our understanding of ovarian tumor immunology. We outline an integrative approach including local and systemic immunity in ovarian cancer. Understanding the nature of both localized and systemic immune responses will be crucial to boosting the efficacy of immunotherapies in ovarian cancer patients.
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spelling pubmed-96847072022-11-25 Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy Rajtak, Alicja Ostrowska-Leśko, Marta Żak, Klaudia Tarkowski, Rafał Kotarski, Jan Okła, Karolina Front Immunol Immunology Cancer is a disease that induces many local and systemic changes in immunity. The difficult nature of ovarian cancer stems from the lack of characteristic symptoms that contributes to a delayed diagnosis and treatment. Despite the enormous progress in immunotherapy, its efficacy remains limited. The heterogeneity of tumors, lack of diagnostic biomarkers, and complex immune landscape are the main challenges in the treatment of ovarian cancer. Integrative approaches that combine the tumor microenvironment – local immunity – together with periphery – systemic immunity – are urgently needed to improve the understanding of the disease and the efficacy of treatment. In fact, multiparametric analyses are poised to improve our understanding of ovarian tumor immunology. We outline an integrative approach including local and systemic immunity in ovarian cancer. Understanding the nature of both localized and systemic immune responses will be crucial to boosting the efficacy of immunotherapies in ovarian cancer patients. Frontiers Media S.A. 2022-11-10 /pmc/articles/PMC9684707/ /pubmed/36439144 http://dx.doi.org/10.3389/fimmu.2022.1018256 Text en Copyright © 2022 Rajtak, Ostrowska-Leśko, Żak, Tarkowski, Kotarski and Okła https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Rajtak, Alicja
Ostrowska-Leśko, Marta
Żak, Klaudia
Tarkowski, Rafał
Kotarski, Jan
Okła, Karolina
Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy
title Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy
title_full Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy
title_fullStr Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy
title_full_unstemmed Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy
title_short Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy
title_sort integration of local and systemic immunity in ovarian cancer: implications for immunotherapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684707/
https://www.ncbi.nlm.nih.gov/pubmed/36439144
http://dx.doi.org/10.3389/fimmu.2022.1018256
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