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Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy
Cancer is a disease that induces many local and systemic changes in immunity. The difficult nature of ovarian cancer stems from the lack of characteristic symptoms that contributes to a delayed diagnosis and treatment. Despite the enormous progress in immunotherapy, its efficacy remains limited. The...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684707/ https://www.ncbi.nlm.nih.gov/pubmed/36439144 http://dx.doi.org/10.3389/fimmu.2022.1018256 |
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author | Rajtak, Alicja Ostrowska-Leśko, Marta Żak, Klaudia Tarkowski, Rafał Kotarski, Jan Okła, Karolina |
author_facet | Rajtak, Alicja Ostrowska-Leśko, Marta Żak, Klaudia Tarkowski, Rafał Kotarski, Jan Okła, Karolina |
author_sort | Rajtak, Alicja |
collection | PubMed |
description | Cancer is a disease that induces many local and systemic changes in immunity. The difficult nature of ovarian cancer stems from the lack of characteristic symptoms that contributes to a delayed diagnosis and treatment. Despite the enormous progress in immunotherapy, its efficacy remains limited. The heterogeneity of tumors, lack of diagnostic biomarkers, and complex immune landscape are the main challenges in the treatment of ovarian cancer. Integrative approaches that combine the tumor microenvironment – local immunity – together with periphery – systemic immunity – are urgently needed to improve the understanding of the disease and the efficacy of treatment. In fact, multiparametric analyses are poised to improve our understanding of ovarian tumor immunology. We outline an integrative approach including local and systemic immunity in ovarian cancer. Understanding the nature of both localized and systemic immune responses will be crucial to boosting the efficacy of immunotherapies in ovarian cancer patients. |
format | Online Article Text |
id | pubmed-9684707 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96847072022-11-25 Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy Rajtak, Alicja Ostrowska-Leśko, Marta Żak, Klaudia Tarkowski, Rafał Kotarski, Jan Okła, Karolina Front Immunol Immunology Cancer is a disease that induces many local and systemic changes in immunity. The difficult nature of ovarian cancer stems from the lack of characteristic symptoms that contributes to a delayed diagnosis and treatment. Despite the enormous progress in immunotherapy, its efficacy remains limited. The heterogeneity of tumors, lack of diagnostic biomarkers, and complex immune landscape are the main challenges in the treatment of ovarian cancer. Integrative approaches that combine the tumor microenvironment – local immunity – together with periphery – systemic immunity – are urgently needed to improve the understanding of the disease and the efficacy of treatment. In fact, multiparametric analyses are poised to improve our understanding of ovarian tumor immunology. We outline an integrative approach including local and systemic immunity in ovarian cancer. Understanding the nature of both localized and systemic immune responses will be crucial to boosting the efficacy of immunotherapies in ovarian cancer patients. Frontiers Media S.A. 2022-11-10 /pmc/articles/PMC9684707/ /pubmed/36439144 http://dx.doi.org/10.3389/fimmu.2022.1018256 Text en Copyright © 2022 Rajtak, Ostrowska-Leśko, Żak, Tarkowski, Kotarski and Okła https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Rajtak, Alicja Ostrowska-Leśko, Marta Żak, Klaudia Tarkowski, Rafał Kotarski, Jan Okła, Karolina Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy |
title | Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy |
title_full | Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy |
title_fullStr | Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy |
title_full_unstemmed | Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy |
title_short | Integration of local and systemic immunity in ovarian cancer: Implications for immunotherapy |
title_sort | integration of local and systemic immunity in ovarian cancer: implications for immunotherapy |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684707/ https://www.ncbi.nlm.nih.gov/pubmed/36439144 http://dx.doi.org/10.3389/fimmu.2022.1018256 |
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