3,3′-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction. The pathological mechanisms are complex; in particular, inflammation, autophagy, and apoptosis are often involved. 3,3-Diindolylmethane (DIM), a phytoconstituent extracted from cruciferous v...

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Detalles Bibliográficos
Autores principales: Tang, Hao, Qin, Kunpeng, Wang, Anquan, Li, Shuang, Fang, Sheng, Gao, Weilu, Lu, Ming, Huang, Wei, Zhang, Hui, Yin, Zongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684728/
https://www.ncbi.nlm.nih.gov/pubmed/36438802
http://dx.doi.org/10.3389/fphar.2022.999851

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