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Monitoring hypertensive disorders in pregnancy to prevent preeclampsia in pregnant women of advanced maternal age: Trial mimicking with retrospective data

This study investigated the implication of monitoring hypertensive disorders in pregnancy (HDP) to prevent preeclampsia (PE) in pregnant women of advanced maternal age. Between January 2016 and April 2021, 262 consecutive pregnant women aged ≥40 years were recruited. Extensive monitoring of hyperten...

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Autores principales: Deng, Yali, She, Lifei, Li, Xiaoye, Lai, Weisi, Yu, Ling, Zhang, Wen, Nie, Yanting, Xiao, Songyuan, Liu, Hongyu, Zhou, Yang, Luo, Ting, Deng, Wen, Liu, Jinyu, Zhou, Xihong, Wen, Ying, Zhong, Yanhong, Xiao, Lingyi, Ding, Yiling, Peng, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684737/
https://www.ncbi.nlm.nih.gov/pubmed/36475063
http://dx.doi.org/10.1515/med-2022-0560
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author Deng, Yali
She, Lifei
Li, Xiaoye
Lai, Weisi
Yu, Ling
Zhang, Wen
Nie, Yanting
Xiao, Songyuan
Liu, Hongyu
Zhou, Yang
Luo, Ting
Deng, Wen
Liu, Jinyu
Zhou, Xihong
Wen, Ying
Zhong, Yanhong
Xiao, Lingyi
Ding, Yiling
Peng, Mei
author_facet Deng, Yali
She, Lifei
Li, Xiaoye
Lai, Weisi
Yu, Ling
Zhang, Wen
Nie, Yanting
Xiao, Songyuan
Liu, Hongyu
Zhou, Yang
Luo, Ting
Deng, Wen
Liu, Jinyu
Zhou, Xihong
Wen, Ying
Zhong, Yanhong
Xiao, Lingyi
Ding, Yiling
Peng, Mei
author_sort Deng, Yali
collection PubMed
description This study investigated the implication of monitoring hypertensive disorders in pregnancy (HDP) to prevent preeclampsia (PE) in pregnant women of advanced maternal age. Between January 2016 and April 2021, 262 consecutive pregnant women aged ≥40 years were recruited. Extensive monitoring of hypertensive disorders in pregnancy, including blood hypercoagulability screening and subsequent interventions, was performed in 129 pregnant women in our university hospital. The remaining 133 patients from other centres, who did not receive antenatal maternal pregnancy screening and preventive intervention during the same period, constituted the non-intervention group enabling comparison to mimic a trial. The incidences of hypertensive disorders, mild and severe PE, eclampsia, and chronic hypertension complicated by PE in the intervention group were significantly lower than in the non-intervention group (10.08 versus 20.30%, 8.52 versus 18.80%, 7.75 versus 21.05%, 0 versus 3.01%, and 3.86 versus 15.04%, respectively; P < 0.05). Premature birth, low birth weight, and foetal loss were significantly rarer in the intervention group than in the non-intervention group (6.98 versus 24.81%, 7.75 versus 21.80%, and 0.78 versus 14.29% respectively; P < 0.001). The comparison of MP with routine blood coagulation biochemical examination found that the MP detection system of Beijing Yes Medical Devices Co., Ltd., had similar sensitivity as thromboelastogram. Still, it was significantly better than the routine biochemical indicators (P < 0.01). Based on MP parameters, early anticoagulant treatment with low-molecular-weight heparin or low-dose aspirin in pregnant women with hypercoagulability can effectively prevent the occurrence of PE and significantly improve the prognosis of both mothers and infants.
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spelling pubmed-96847372022-12-05 Monitoring hypertensive disorders in pregnancy to prevent preeclampsia in pregnant women of advanced maternal age: Trial mimicking with retrospective data Deng, Yali She, Lifei Li, Xiaoye Lai, Weisi Yu, Ling Zhang, Wen Nie, Yanting Xiao, Songyuan Liu, Hongyu Zhou, Yang Luo, Ting Deng, Wen Liu, Jinyu Zhou, Xihong Wen, Ying Zhong, Yanhong Xiao, Lingyi Ding, Yiling Peng, Mei Open Med (Wars) Research Article This study investigated the implication of monitoring hypertensive disorders in pregnancy (HDP) to prevent preeclampsia (PE) in pregnant women of advanced maternal age. Between January 2016 and April 2021, 262 consecutive pregnant women aged ≥40 years were recruited. Extensive monitoring of hypertensive disorders in pregnancy, including blood hypercoagulability screening and subsequent interventions, was performed in 129 pregnant women in our university hospital. The remaining 133 patients from other centres, who did not receive antenatal maternal pregnancy screening and preventive intervention during the same period, constituted the non-intervention group enabling comparison to mimic a trial. The incidences of hypertensive disorders, mild and severe PE, eclampsia, and chronic hypertension complicated by PE in the intervention group were significantly lower than in the non-intervention group (10.08 versus 20.30%, 8.52 versus 18.80%, 7.75 versus 21.05%, 0 versus 3.01%, and 3.86 versus 15.04%, respectively; P < 0.05). Premature birth, low birth weight, and foetal loss were significantly rarer in the intervention group than in the non-intervention group (6.98 versus 24.81%, 7.75 versus 21.80%, and 0.78 versus 14.29% respectively; P < 0.001). The comparison of MP with routine blood coagulation biochemical examination found that the MP detection system of Beijing Yes Medical Devices Co., Ltd., had similar sensitivity as thromboelastogram. Still, it was significantly better than the routine biochemical indicators (P < 0.01). Based on MP parameters, early anticoagulant treatment with low-molecular-weight heparin or low-dose aspirin in pregnant women with hypercoagulability can effectively prevent the occurrence of PE and significantly improve the prognosis of both mothers and infants. De Gruyter 2022-11-22 /pmc/articles/PMC9684737/ /pubmed/36475063 http://dx.doi.org/10.1515/med-2022-0560 Text en © 2022 the author(s), published by De Gruyter https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
Deng, Yali
She, Lifei
Li, Xiaoye
Lai, Weisi
Yu, Ling
Zhang, Wen
Nie, Yanting
Xiao, Songyuan
Liu, Hongyu
Zhou, Yang
Luo, Ting
Deng, Wen
Liu, Jinyu
Zhou, Xihong
Wen, Ying
Zhong, Yanhong
Xiao, Lingyi
Ding, Yiling
Peng, Mei
Monitoring hypertensive disorders in pregnancy to prevent preeclampsia in pregnant women of advanced maternal age: Trial mimicking with retrospective data
title Monitoring hypertensive disorders in pregnancy to prevent preeclampsia in pregnant women of advanced maternal age: Trial mimicking with retrospective data
title_full Monitoring hypertensive disorders in pregnancy to prevent preeclampsia in pregnant women of advanced maternal age: Trial mimicking with retrospective data
title_fullStr Monitoring hypertensive disorders in pregnancy to prevent preeclampsia in pregnant women of advanced maternal age: Trial mimicking with retrospective data
title_full_unstemmed Monitoring hypertensive disorders in pregnancy to prevent preeclampsia in pregnant women of advanced maternal age: Trial mimicking with retrospective data
title_short Monitoring hypertensive disorders in pregnancy to prevent preeclampsia in pregnant women of advanced maternal age: Trial mimicking with retrospective data
title_sort monitoring hypertensive disorders in pregnancy to prevent preeclampsia in pregnant women of advanced maternal age: trial mimicking with retrospective data
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684737/
https://www.ncbi.nlm.nih.gov/pubmed/36475063
http://dx.doi.org/10.1515/med-2022-0560
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