A common variant close to the “tripwire” linker region of NLRP1 contributes to severe COVID-19

OBJECTIVE AND DESIGN: The heterogeneity of response to SARS-CoV-2 infection is directly linked to the individual genetic background. Genetic variants of inflammasome-related genes have been pointed as risk factors for several inflammatory sterile and infectious disease. In the group of inflammasome...

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Detalles Bibliográficos
Autores principales: Leal, Vinicius N. C., Paulino, Leandro M., Cambui, Raylane A. G., Zupelli, Thiago G., Yamada, Suemy M., Oliveira, Leonardo A. T., Dutra, Valéria de F., Bub, Carolina B., Sakashita, Araci M., Yokoyama, Ana Paula H., Kutner, José M., Vieira, Camila A., Santiago, Wellyngton M. de S., Andrade, Milena M. S., Teixeira, Franciane M. E., Alberca, Ricardo W., Gozzi-Silva, Sarah C., Yendo, Tatiana M., Netto, Lucas C., Duarte, Alberto J. S., Sato, Maria N., Venturini, James, Pontillo, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684769/
https://www.ncbi.nlm.nih.gov/pubmed/36416944
http://dx.doi.org/10.1007/s00011-022-01670-3
Descripción
Sumario:OBJECTIVE AND DESIGN: The heterogeneity of response to SARS-CoV-2 infection is directly linked to the individual genetic background. Genetic variants of inflammasome-related genes have been pointed as risk factors for several inflammatory sterile and infectious disease. In the group of inflammasome receptors, NLRP1 stands out as a good novel candidate as severity factor for COVID-19 disease. METHODS: To address this question, we performed an association study of NLRP1, DPP9, CARD8, IL1B, and IL18 single nucleotide variants (SNVs) in a cohort of 945 COVID-19 patients. RESULTS: The NLRP1 p.Leu155His in the linker region, target of viral protease, was significantly associated to COVID-19 severity, which could contribute to the excessive cytokine release reported in severe cases. CONCLUSION: Inflammasome genetic background contributes to individual response to SARS-CoV-2. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00011-022-01670-3.

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