Oncosuppressive miRNAs loaded in lipid nanoparticles potentiate targeted therapies in BRAF-mutant melanoma by inhibiting core escape pathways of resistance

BRAF-mutated melanoma relapsing after targeted therapies is an aggressive disease with unmet clinical need. Hence the need to identify novel combination therapies able to overcome drug resistance. miRNAs have emerged as orchestrators of non-genetic mechanisms adopted by melanoma cells to challenge t...

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Detalles Bibliográficos
Autores principales: Fattore, Luigi, Cafaro, Giordana, Di Martile, Marta, Campani, Virginia, Sacconi, Andrea, Liguoro, Domenico, Marra, Emanuele, Bruschini, Sara, Stoppoloni, Daniela, Cirombella, Roberto, De Nicola, Francesca, Pallocca, Matteo, Ruggiero, Ciro F., Castaldo, Vittorio, Catizone, Angiolina, Del Bufalo, Donatella, Viglietto, Giuseppe, Vecchione, Andrea, Blandino, Giovanni, Aurisicchio, Luigi, Fanciulli, Maurizio, Ascierto, Paolo A., De Rosa, Giuseppe, Mancini, Rita, Ciliberto, Gennaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684877/
https://www.ncbi.nlm.nih.gov/pubmed/36418472
http://dx.doi.org/10.1038/s41388-022-02547-9

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