Transcription factor Nrf2 as a potential therapeutic target for COVID-19

The coronavirus disease 2019 (COVID-19) is caused by a novel severe acute respiratory syndrome (SARS)–like coronavirus (SARS-CoV-2). Critically ill patients with SARS-COV-2 infection frequently exhibit signs of high oxidative stress and systemic inflammation, which accounts for most of the mortality...

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Detalles Bibliográficos
Autores principales: Wang, Yifan, Ma, Jing, Jiang, Yongfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685020/
https://www.ncbi.nlm.nih.gov/pubmed/36417098
http://dx.doi.org/10.1007/s12192-022-01296-8
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author Wang, Yifan
Ma, Jing
Jiang, Yongfang
author_facet Wang, Yifan
Ma, Jing
Jiang, Yongfang
author_sort Wang, Yifan
collection PubMed
description The coronavirus disease 2019 (COVID-19) is caused by a novel severe acute respiratory syndrome (SARS)–like coronavirus (SARS-CoV-2). Critically ill patients with SARS-COV-2 infection frequently exhibit signs of high oxidative stress and systemic inflammation, which accounts for most of the mortality. Antiviral strategies to inhibit the pathogenic consequences of COVID-19 are urgently required. The nuclear factor erythroid 2–related transcription factor (Nrf2) is a transcription factor that is involved in antioxidant and anti-inflammatory defense in several tissues and cells. This review tries to present an overview of the role of Nrf2 in the treatment of COVID-19.
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spelling pubmed-96850202022-11-28 Transcription factor Nrf2 as a potential therapeutic target for COVID-19 Wang, Yifan Ma, Jing Jiang, Yongfang Cell Stress Chaperones Mini Review The coronavirus disease 2019 (COVID-19) is caused by a novel severe acute respiratory syndrome (SARS)–like coronavirus (SARS-CoV-2). Critically ill patients with SARS-COV-2 infection frequently exhibit signs of high oxidative stress and systemic inflammation, which accounts for most of the mortality. Antiviral strategies to inhibit the pathogenic consequences of COVID-19 are urgently required. The nuclear factor erythroid 2–related transcription factor (Nrf2) is a transcription factor that is involved in antioxidant and anti-inflammatory defense in several tissues and cells. This review tries to present an overview of the role of Nrf2 in the treatment of COVID-19. Springer Netherlands 2022-11-22 2023-01 /pmc/articles/PMC9685020/ /pubmed/36417098 http://dx.doi.org/10.1007/s12192-022-01296-8 Text en © The Author(s), under exclusive licence to Cell Stress Society International 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
spellingShingle Mini Review
Wang, Yifan
Ma, Jing
Jiang, Yongfang
Transcription factor Nrf2 as a potential therapeutic target for COVID-19
title Transcription factor Nrf2 as a potential therapeutic target for COVID-19
title_full Transcription factor Nrf2 as a potential therapeutic target for COVID-19
title_fullStr Transcription factor Nrf2 as a potential therapeutic target for COVID-19
title_full_unstemmed Transcription factor Nrf2 as a potential therapeutic target for COVID-19
title_short Transcription factor Nrf2 as a potential therapeutic target for COVID-19
title_sort transcription factor nrf2 as a potential therapeutic target for covid-19
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685020/
https://www.ncbi.nlm.nih.gov/pubmed/36417098
http://dx.doi.org/10.1007/s12192-022-01296-8
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