Systemic inflammation and risk of multiple sclerosis – A presymptomatic case-control study

BACKGROUND: C-reactive protein (CRP) is a marker of systemic inflammation. Increased levels of CRP in young persons have been suggested to decrease the risk of multiple sclerosis (MS). OBJECTIVES: To assess CRP as a risk factor for MS. METHODS: Levels of CRP were measured with a high-sensitive immun...

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Detalles Bibliográficos
Autores principales: Grut, Viktor, Biström, Martin, Salzer, Jonatan, Stridh, Pernilla, Lindam, Anna, Alonso-Magdalena, Lucia, Andersen, Oluf, Jons, Daniel, Gunnarsson, Martin, Vrethem, Magnus, Hultdin, Johan, Sundström, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685111/
https://www.ncbi.nlm.nih.gov/pubmed/36440320
http://dx.doi.org/10.1177/20552173221139768
Descripción
Sumario:BACKGROUND: C-reactive protein (CRP) is a marker of systemic inflammation. Increased levels of CRP in young persons have been suggested to decrease the risk of multiple sclerosis (MS). OBJECTIVES: To assess CRP as a risk factor for MS. METHODS: Levels of CRP were measured with a high-sensitive immunoassay in biobank samples from 837 individuals who later developed MS and 984 matched controls. The risk of developing MS was analysed by conditional logistic regression on z-scored CRP values. RESULTS: Levels of CRP were not associated with MS risk. CONCLUSIONS: We found no association between CRP levels and risk of MS development.

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