Systemic inflammation and risk of multiple sclerosis – A presymptomatic case-control study

BACKGROUND: C-reactive protein (CRP) is a marker of systemic inflammation. Increased levels of CRP in young persons have been suggested to decrease the risk of multiple sclerosis (MS). OBJECTIVES: To assess CRP as a risk factor for MS. METHODS: Levels of CRP were measured with a high-sensitive immun...

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Autores principales: Grut, Viktor, Biström, Martin, Salzer, Jonatan, Stridh, Pernilla, Lindam, Anna, Alonso-Magdalena, Lucia, Andersen, Oluf, Jons, Daniel, Gunnarsson, Martin, Vrethem, Magnus, Hultdin, Johan, Sundström, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685111/
https://www.ncbi.nlm.nih.gov/pubmed/36440320
http://dx.doi.org/10.1177/20552173221139768
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author Grut, Viktor
Biström, Martin
Salzer, Jonatan
Stridh, Pernilla
Lindam, Anna
Alonso-Magdalena, Lucia
Andersen, Oluf
Jons, Daniel
Gunnarsson, Martin
Vrethem, Magnus
Hultdin, Johan
Sundström, Peter
author_facet Grut, Viktor
Biström, Martin
Salzer, Jonatan
Stridh, Pernilla
Lindam, Anna
Alonso-Magdalena, Lucia
Andersen, Oluf
Jons, Daniel
Gunnarsson, Martin
Vrethem, Magnus
Hultdin, Johan
Sundström, Peter
author_sort Grut, Viktor
collection PubMed
description BACKGROUND: C-reactive protein (CRP) is a marker of systemic inflammation. Increased levels of CRP in young persons have been suggested to decrease the risk of multiple sclerosis (MS). OBJECTIVES: To assess CRP as a risk factor for MS. METHODS: Levels of CRP were measured with a high-sensitive immunoassay in biobank samples from 837 individuals who later developed MS and 984 matched controls. The risk of developing MS was analysed by conditional logistic regression on z-scored CRP values. RESULTS: Levels of CRP were not associated with MS risk. CONCLUSIONS: We found no association between CRP levels and risk of MS development.
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spelling pubmed-96851112022-11-25 Systemic inflammation and risk of multiple sclerosis – A presymptomatic case-control study Grut, Viktor Biström, Martin Salzer, Jonatan Stridh, Pernilla Lindam, Anna Alonso-Magdalena, Lucia Andersen, Oluf Jons, Daniel Gunnarsson, Martin Vrethem, Magnus Hultdin, Johan Sundström, Peter Mult Scler J Exp Transl Clin Brief Report BACKGROUND: C-reactive protein (CRP) is a marker of systemic inflammation. Increased levels of CRP in young persons have been suggested to decrease the risk of multiple sclerosis (MS). OBJECTIVES: To assess CRP as a risk factor for MS. METHODS: Levels of CRP were measured with a high-sensitive immunoassay in biobank samples from 837 individuals who later developed MS and 984 matched controls. The risk of developing MS was analysed by conditional logistic regression on z-scored CRP values. RESULTS: Levels of CRP were not associated with MS risk. CONCLUSIONS: We found no association between CRP levels and risk of MS development. SAGE Publications 2022-11-22 /pmc/articles/PMC9685111/ /pubmed/36440320 http://dx.doi.org/10.1177/20552173221139768 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Brief Report
Grut, Viktor
Biström, Martin
Salzer, Jonatan
Stridh, Pernilla
Lindam, Anna
Alonso-Magdalena, Lucia
Andersen, Oluf
Jons, Daniel
Gunnarsson, Martin
Vrethem, Magnus
Hultdin, Johan
Sundström, Peter
Systemic inflammation and risk of multiple sclerosis – A presymptomatic case-control study
title Systemic inflammation and risk of multiple sclerosis – A presymptomatic case-control study
title_full Systemic inflammation and risk of multiple sclerosis – A presymptomatic case-control study
title_fullStr Systemic inflammation and risk of multiple sclerosis – A presymptomatic case-control study
title_full_unstemmed Systemic inflammation and risk of multiple sclerosis – A presymptomatic case-control study
title_short Systemic inflammation and risk of multiple sclerosis – A presymptomatic case-control study
title_sort systemic inflammation and risk of multiple sclerosis – a presymptomatic case-control study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685111/
https://www.ncbi.nlm.nih.gov/pubmed/36440320
http://dx.doi.org/10.1177/20552173221139768
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