Alzheimer’s disease and epilepsy: An increasingly recognized comorbidity

Both Alzheimer’s disease (AD) and epilepsy are common chronic diseases in older people. Seizures and epileptiform discharges are very prevalent in AD and can occur since any stage of AD. Increasing evidence indicates that AD and epilepsy may be comorbid. Several factors may be related to the underly...

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Autores principales: Yang, Fei, Chen, Liling, Yu, Yanying, Xu, Tingwan, Chen, Lu, Yang, Wenqian, Wu, Qian, Han, Yanbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685172/
https://www.ncbi.nlm.nih.gov/pubmed/36438002
http://dx.doi.org/10.3389/fnagi.2022.940515
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author Yang, Fei
Chen, Liling
Yu, Yanying
Xu, Tingwan
Chen, Lu
Yang, Wenqian
Wu, Qian
Han, Yanbing
author_facet Yang, Fei
Chen, Liling
Yu, Yanying
Xu, Tingwan
Chen, Lu
Yang, Wenqian
Wu, Qian
Han, Yanbing
author_sort Yang, Fei
collection PubMed
description Both Alzheimer’s disease (AD) and epilepsy are common chronic diseases in older people. Seizures and epileptiform discharges are very prevalent in AD and can occur since any stage of AD. Increasing evidence indicates that AD and epilepsy may be comorbid. Several factors may be related to the underlying mechanism of the comorbidity. Identifying seizures in patients with AD is a challenge because seizures are often clinically non-motor and may overlap with some AD symptoms. Not only seizures but also epileptiform discharges may exacerbate the cognitive decline in AD patients, highlighting the importance of early recognition and treatment. This review provides a comprehensive overview of seizures in AD from multiple aspects to provide more insight.
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spelling pubmed-96851722022-11-25 Alzheimer’s disease and epilepsy: An increasingly recognized comorbidity Yang, Fei Chen, Liling Yu, Yanying Xu, Tingwan Chen, Lu Yang, Wenqian Wu, Qian Han, Yanbing Front Aging Neurosci Aging Neuroscience Both Alzheimer’s disease (AD) and epilepsy are common chronic diseases in older people. Seizures and epileptiform discharges are very prevalent in AD and can occur since any stage of AD. Increasing evidence indicates that AD and epilepsy may be comorbid. Several factors may be related to the underlying mechanism of the comorbidity. Identifying seizures in patients with AD is a challenge because seizures are often clinically non-motor and may overlap with some AD symptoms. Not only seizures but also epileptiform discharges may exacerbate the cognitive decline in AD patients, highlighting the importance of early recognition and treatment. This review provides a comprehensive overview of seizures in AD from multiple aspects to provide more insight. Frontiers Media S.A. 2022-11-10 /pmc/articles/PMC9685172/ /pubmed/36438002 http://dx.doi.org/10.3389/fnagi.2022.940515 Text en Copyright © 2022 Yang, Chen, Yu, Xu, Chen, Yang, Wu and Han. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Yang, Fei
Chen, Liling
Yu, Yanying
Xu, Tingwan
Chen, Lu
Yang, Wenqian
Wu, Qian
Han, Yanbing
Alzheimer’s disease and epilepsy: An increasingly recognized comorbidity
title Alzheimer’s disease and epilepsy: An increasingly recognized comorbidity
title_full Alzheimer’s disease and epilepsy: An increasingly recognized comorbidity
title_fullStr Alzheimer’s disease and epilepsy: An increasingly recognized comorbidity
title_full_unstemmed Alzheimer’s disease and epilepsy: An increasingly recognized comorbidity
title_short Alzheimer’s disease and epilepsy: An increasingly recognized comorbidity
title_sort alzheimer’s disease and epilepsy: an increasingly recognized comorbidity
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685172/
https://www.ncbi.nlm.nih.gov/pubmed/36438002
http://dx.doi.org/10.3389/fnagi.2022.940515
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