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Management of early graft candidiasis in a kidney transplant recipient

Balancing adequate immunosuppression with the risk of infection after renal transplantation remains a challenge. The presence of comorbidities adds to the challenge. Although infrequent, invasive fungal infections result in high morbidity and mortality risk in renal transplant recipients. This can b...

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Autores principales: Tan, Jaimee, Wild, Abigail, Reid, Graeme, Shantier, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685235/
https://www.ncbi.nlm.nih.gov/pubmed/36414350
http://dx.doi.org/10.1136/bcr-2022-250890
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author Tan, Jaimee
Wild, Abigail
Reid, Graeme
Shantier, Mohamed
author_facet Tan, Jaimee
Wild, Abigail
Reid, Graeme
Shantier, Mohamed
author_sort Tan, Jaimee
collection PubMed
description Balancing adequate immunosuppression with the risk of infection after renal transplantation remains a challenge. The presence of comorbidities adds to the challenge. Although infrequent, invasive fungal infections result in high morbidity and mortality risk in renal transplant recipients. This can be attributed to the intense immunosuppression in the first 6 months after renal transplantation, minimal symptomatology and the high mortality associated with fungal infections. Due to minimal available evidence, clinical judgement guides management of graft candidiasis. There is a need to develop evidence-based management guidelines for the treatment of fungal infections in renal transplants. Here, we report a case of early-onset candidiasis in a transplanted kidney and present the histological findings, multidisciplinary discussions and treatment given.
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spelling pubmed-96852352022-11-25 Management of early graft candidiasis in a kidney transplant recipient Tan, Jaimee Wild, Abigail Reid, Graeme Shantier, Mohamed BMJ Case Rep Case Reports: Learning from unexpected outcome (positive or negative) Balancing adequate immunosuppression with the risk of infection after renal transplantation remains a challenge. The presence of comorbidities adds to the challenge. Although infrequent, invasive fungal infections result in high morbidity and mortality risk in renal transplant recipients. This can be attributed to the intense immunosuppression in the first 6 months after renal transplantation, minimal symptomatology and the high mortality associated with fungal infections. Due to minimal available evidence, clinical judgement guides management of graft candidiasis. There is a need to develop evidence-based management guidelines for the treatment of fungal infections in renal transplants. Here, we report a case of early-onset candidiasis in a transplanted kidney and present the histological findings, multidisciplinary discussions and treatment given. BMJ Publishing Group 2022-11-22 /pmc/articles/PMC9685235/ /pubmed/36414350 http://dx.doi.org/10.1136/bcr-2022-250890 Text en © BMJ Publishing Group Limited 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Case Reports: Learning from unexpected outcome (positive or negative)
Tan, Jaimee
Wild, Abigail
Reid, Graeme
Shantier, Mohamed
Management of early graft candidiasis in a kidney transplant recipient
title Management of early graft candidiasis in a kidney transplant recipient
title_full Management of early graft candidiasis in a kidney transplant recipient
title_fullStr Management of early graft candidiasis in a kidney transplant recipient
title_full_unstemmed Management of early graft candidiasis in a kidney transplant recipient
title_short Management of early graft candidiasis in a kidney transplant recipient
title_sort management of early graft candidiasis in a kidney transplant recipient
topic Case Reports: Learning from unexpected outcome (positive or negative)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685235/
https://www.ncbi.nlm.nih.gov/pubmed/36414350
http://dx.doi.org/10.1136/bcr-2022-250890
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