MSCs can be a double-edged sword in tumorigenesis

Mesenchymal stem cells (MSCs) have been used to treat various diseases including Alzheimer’s disease and cancer. In particular, the immunomodulatory function of MSCs plays a major role in cancer therapy using stem cells. However, MSCs exert promotive and inhibitory effects on cancer. The immunomodul...

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Detalles Bibliográficos
Autores principales: Zhang, Lu, Xiang, Junyu, Zhang, Fang, Liu, Limei, Hu, Chongling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685321/
https://www.ncbi.nlm.nih.gov/pubmed/36439438
http://dx.doi.org/10.3389/fonc.2022.1047907
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author Zhang, Lu
Xiang, Junyu
Zhang, Fang
Liu, Limei
Hu, Chongling
author_facet Zhang, Lu
Xiang, Junyu
Zhang, Fang
Liu, Limei
Hu, Chongling
author_sort Zhang, Lu
collection PubMed
description Mesenchymal stem cells (MSCs) have been used to treat various diseases including Alzheimer’s disease and cancer. In particular, the immunomodulatory function of MSCs plays a major role in cancer therapy using stem cells. However, MSCs exert promotive and inhibitory effects on cancer. The immunomodulatory effects of MSCs in the tumor microenvironment (TME) are ambiguous, which is the primary reason for the different outcomes of MSCs therapies for tumors. This review discusses the use of MSCs in cancer immunotherapy and their immunomodulatory mechanisms in cancers.
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spelling pubmed-96853212022-11-25 MSCs can be a double-edged sword in tumorigenesis Zhang, Lu Xiang, Junyu Zhang, Fang Liu, Limei Hu, Chongling Front Oncol Oncology Mesenchymal stem cells (MSCs) have been used to treat various diseases including Alzheimer’s disease and cancer. In particular, the immunomodulatory function of MSCs plays a major role in cancer therapy using stem cells. However, MSCs exert promotive and inhibitory effects on cancer. The immunomodulatory effects of MSCs in the tumor microenvironment (TME) are ambiguous, which is the primary reason for the different outcomes of MSCs therapies for tumors. This review discusses the use of MSCs in cancer immunotherapy and their immunomodulatory mechanisms in cancers. Frontiers Media S.A. 2022-11-10 /pmc/articles/PMC9685321/ /pubmed/36439438 http://dx.doi.org/10.3389/fonc.2022.1047907 Text en Copyright © 2022 Zhang, Xiang, Zhang, Liu and Hu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Lu
Xiang, Junyu
Zhang, Fang
Liu, Limei
Hu, Chongling
MSCs can be a double-edged sword in tumorigenesis
title MSCs can be a double-edged sword in tumorigenesis
title_full MSCs can be a double-edged sword in tumorigenesis
title_fullStr MSCs can be a double-edged sword in tumorigenesis
title_full_unstemmed MSCs can be a double-edged sword in tumorigenesis
title_short MSCs can be a double-edged sword in tumorigenesis
title_sort mscs can be a double-edged sword in tumorigenesis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685321/
https://www.ncbi.nlm.nih.gov/pubmed/36439438
http://dx.doi.org/10.3389/fonc.2022.1047907
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AT huchongling mscscanbeadoubleedgedswordintumorigenesis

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