Downregulation of SOCS1 increases interferon-induced ISGylation during differentiation of induced-pluripotent stem cells to hepatocytes

BACKGROUND & AIMS: Increased expression of IFN-stimulated gene 15 (ISG15) and subsequently increased ISGylation are key factors in the host response to viral infection. In this study, we sought to characterize the expression of ISG15, ISGylation, and associated enzymes at each stage of different...

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Detalles Bibliográficos
Autores principales: Edwards, Jasmine S., Delabat, Stephanie A., Badilla, Alejandro D., DiCaprio, Robert C., Hyun, Jinhee, Burgess, Robert A., Silva, Tiago, Dykxhoorn, Derek M., Chen, Steven Xi, Wang, Lily, Ishida, Yuji, Saito, Takeshi, Thomas, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685392/
https://www.ncbi.nlm.nih.gov/pubmed/36439639
http://dx.doi.org/10.1016/j.jhepr.2022.100592

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