Autologous organoid co-culture model reveals T cell-driven epithelial cell death in Crohn’s Disease

Lympho-epithelial interactions between intestinal T resident memory cells (Trm) and the epithelium have been associated with inflammatory bowel disease (IBD) activity. We developed ex vivo autologous organoid-mucosal T cell cocultures to functionally assess lymphoepithelial interactions in Crohn’s D...

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Detalles Bibliográficos
Autores principales: Hammoudi, Nassim, Hamoudi, Sarah, Bonnereau, Julie, Bottois, Hugo, Pérez, Kevin, Bezault, Madeleine, Hassid, Déborah, Chardiny, Victor, Grand, Céline, Gergaud, Brice, Bonnet, Joëlle, Chedouba, Leila, Tran Minh, My-Linh, Gornet, Jean-Marc, Baudry, Clotilde, Corte, Hélène, Maggiori, Léon, Toubert, Antoine, McBride, Jacqueline, Brochier, Camille, Neighbors, Margaret, Le Bourhis, Lionel, Allez, Matthieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685428/
https://www.ncbi.nlm.nih.gov/pubmed/36439157
http://dx.doi.org/10.3389/fimmu.2022.1008456

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