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Hydrogenated Germanene Nanosheets as an Antioxidative Defense Agent for Acute Kidney Injury Treatment

Acute kidney injury (AKI) is a sudden kidney dysfunction caused by aberrant reactive oxygen species (ROS) metabolism that results in high clinical mortality. The rapid development of ROS scavengers provides new opportunities for AKI treatment. Herein, the use of hydrogen‐terminated germanene (H‐germ...

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Autores principales: Chen, Zhixin, Qi, Fenggang, Qiu, Wujie, Wu, Chenyao, Zong, Ming, Ge, Min, Xu, Deliang, You, Yanling, Zhu, Ya‐Xuan, Zhang, Zhimin, Lin, Han, Shi, Jianlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685437/
https://www.ncbi.nlm.nih.gov/pubmed/36202760
http://dx.doi.org/10.1002/advs.202202933
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author Chen, Zhixin
Qi, Fenggang
Qiu, Wujie
Wu, Chenyao
Zong, Ming
Ge, Min
Xu, Deliang
You, Yanling
Zhu, Ya‐Xuan
Zhang, Zhimin
Lin, Han
Shi, Jianlin
author_facet Chen, Zhixin
Qi, Fenggang
Qiu, Wujie
Wu, Chenyao
Zong, Ming
Ge, Min
Xu, Deliang
You, Yanling
Zhu, Ya‐Xuan
Zhang, Zhimin
Lin, Han
Shi, Jianlin
author_sort Chen, Zhixin
collection PubMed
description Acute kidney injury (AKI) is a sudden kidney dysfunction caused by aberrant reactive oxygen species (ROS) metabolism that results in high clinical mortality. The rapid development of ROS scavengers provides new opportunities for AKI treatment. Herein, the use of hydrogen‐terminated germanene (H‐germanene) nanosheets is reported as an antioxidative defense nanoplatform against AKI in mice. The simulation results show that 2D H‐germanene can effectively scavenge ROS through free radical adsorption and subsequent redox reactions. In particular, the H‐germanene exhibits high accumulation in injured kidneys, thereby offering a favorable opportunity for treating renal diseases. In the glycerol‐induced murine AKI model, H‐germanene delivers robust antioxidative protection against ROS attack to maintain normal kidney function indicators without negative influence in vivo. This positive in vivo antioxidative defense in living animals demonstrates that the present H‐germanene nanoplatform is a powerful antioxidant against AKI and various anti‐inflammatory diseases.
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spelling pubmed-96854372022-11-25 Hydrogenated Germanene Nanosheets as an Antioxidative Defense Agent for Acute Kidney Injury Treatment Chen, Zhixin Qi, Fenggang Qiu, Wujie Wu, Chenyao Zong, Ming Ge, Min Xu, Deliang You, Yanling Zhu, Ya‐Xuan Zhang, Zhimin Lin, Han Shi, Jianlin Adv Sci (Weinh) Research Articles Acute kidney injury (AKI) is a sudden kidney dysfunction caused by aberrant reactive oxygen species (ROS) metabolism that results in high clinical mortality. The rapid development of ROS scavengers provides new opportunities for AKI treatment. Herein, the use of hydrogen‐terminated germanene (H‐germanene) nanosheets is reported as an antioxidative defense nanoplatform against AKI in mice. The simulation results show that 2D H‐germanene can effectively scavenge ROS through free radical adsorption and subsequent redox reactions. In particular, the H‐germanene exhibits high accumulation in injured kidneys, thereby offering a favorable opportunity for treating renal diseases. In the glycerol‐induced murine AKI model, H‐germanene delivers robust antioxidative protection against ROS attack to maintain normal kidney function indicators without negative influence in vivo. This positive in vivo antioxidative defense in living animals demonstrates that the present H‐germanene nanoplatform is a powerful antioxidant against AKI and various anti‐inflammatory diseases. John Wiley and Sons Inc. 2022-10-06 /pmc/articles/PMC9685437/ /pubmed/36202760 http://dx.doi.org/10.1002/advs.202202933 Text en © 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Chen, Zhixin
Qi, Fenggang
Qiu, Wujie
Wu, Chenyao
Zong, Ming
Ge, Min
Xu, Deliang
You, Yanling
Zhu, Ya‐Xuan
Zhang, Zhimin
Lin, Han
Shi, Jianlin
Hydrogenated Germanene Nanosheets as an Antioxidative Defense Agent for Acute Kidney Injury Treatment
title Hydrogenated Germanene Nanosheets as an Antioxidative Defense Agent for Acute Kidney Injury Treatment
title_full Hydrogenated Germanene Nanosheets as an Antioxidative Defense Agent for Acute Kidney Injury Treatment
title_fullStr Hydrogenated Germanene Nanosheets as an Antioxidative Defense Agent for Acute Kidney Injury Treatment
title_full_unstemmed Hydrogenated Germanene Nanosheets as an Antioxidative Defense Agent for Acute Kidney Injury Treatment
title_short Hydrogenated Germanene Nanosheets as an Antioxidative Defense Agent for Acute Kidney Injury Treatment
title_sort hydrogenated germanene nanosheets as an antioxidative defense agent for acute kidney injury treatment
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685437/
https://www.ncbi.nlm.nih.gov/pubmed/36202760
http://dx.doi.org/10.1002/advs.202202933
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