A phase I/II escalation trial design T-RAD: Treatment of metastatic lung cancer with mRNA-engineered T cells expressing a T cell receptor targeting human telomerase reverse transcriptase (hTERT)

BACKGROUND: Adoptive cellular therapy (ACT) with genetically modified T cells aims to redirect T cells against resistant cancers through introduction of a T cell receptor (TCR). The Radium-4 TCR was isolated from a responding patient in a cancer vaccination study and recognizes the enzymatic compone...

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Detalles Bibliográficos
Autores principales: Maggadóttir, Sólrún Melkorka, Kvalheim, Gunnar, Wernhoff, Patrik, Sæbøe-Larssen, Stein, Revheim, Mona-Elisabeth, Josefsen, Dag, Wälchli, Sébastien, Helland, Åslaug, Inderberg, Else Marit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685610/
https://www.ncbi.nlm.nih.gov/pubmed/36439452
http://dx.doi.org/10.3389/fonc.2022.1031232

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