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Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases
Poly (ADP-ribose) polymerases (PARPs) constitute of 17 members that are associated with divergent cellular processes and play a crucial role in DNA repair, chromatin organization, genome integrity, apoptosis, and inflammation. Multiple lines of evidence have shown that activated PARP1 is associated...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685622/ https://www.ncbi.nlm.nih.gov/pubmed/36438061 http://dx.doi.org/10.3389/fmed.2022.1062432 |
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author | Tong, Jie Chen, Baosheng Tan, Peng Wen Kurpiewski, Stephen Cai, Zhengxin |
author_facet | Tong, Jie Chen, Baosheng Tan, Peng Wen Kurpiewski, Stephen Cai, Zhengxin |
author_sort | Tong, Jie |
collection | PubMed |
description | Poly (ADP-ribose) polymerases (PARPs) constitute of 17 members that are associated with divergent cellular processes and play a crucial role in DNA repair, chromatin organization, genome integrity, apoptosis, and inflammation. Multiple lines of evidence have shown that activated PARP1 is associated with intense DNA damage and irritating inflammatory responses, which are in turn related to etiologies of various neurological disorders. PARP1/2 as plausible therapeutic targets have attracted considerable interests, and multitudes of PARP1/2 inhibitors have emerged for treating cancer, metabolic, inflammatory, and neurological disorders. Furthermore, PARP1/2 as imaging targets have been shown to detect, delineate, and predict therapeutic responses in many diseases by locating and quantifying the expression levels of PARP1/2. PARP1/2-directed noninvasive positron emission tomography (PET) has potential in diagnosing and prognosing neurological diseases. However, quantitative PARP PET imaging in the central nervous system (CNS) has evaded us due to the challenges of developing blood-brain barrier (BBB) penetrable PARP radioligands. Here, we review PARP1/2's relevance in CNS diseases, summarize the recent progress on PARP PET and discuss the possibilities of developing novel PARP radiotracers for CNS diseases. |
format | Online Article Text |
id | pubmed-9685622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96856222022-11-25 Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases Tong, Jie Chen, Baosheng Tan, Peng Wen Kurpiewski, Stephen Cai, Zhengxin Front Med (Lausanne) Medicine Poly (ADP-ribose) polymerases (PARPs) constitute of 17 members that are associated with divergent cellular processes and play a crucial role in DNA repair, chromatin organization, genome integrity, apoptosis, and inflammation. Multiple lines of evidence have shown that activated PARP1 is associated with intense DNA damage and irritating inflammatory responses, which are in turn related to etiologies of various neurological disorders. PARP1/2 as plausible therapeutic targets have attracted considerable interests, and multitudes of PARP1/2 inhibitors have emerged for treating cancer, metabolic, inflammatory, and neurological disorders. Furthermore, PARP1/2 as imaging targets have been shown to detect, delineate, and predict therapeutic responses in many diseases by locating and quantifying the expression levels of PARP1/2. PARP1/2-directed noninvasive positron emission tomography (PET) has potential in diagnosing and prognosing neurological diseases. However, quantitative PARP PET imaging in the central nervous system (CNS) has evaded us due to the challenges of developing blood-brain barrier (BBB) penetrable PARP radioligands. Here, we review PARP1/2's relevance in CNS diseases, summarize the recent progress on PARP PET and discuss the possibilities of developing novel PARP radiotracers for CNS diseases. Frontiers Media S.A. 2022-11-10 /pmc/articles/PMC9685622/ /pubmed/36438061 http://dx.doi.org/10.3389/fmed.2022.1062432 Text en Copyright © 2022 Tong, Chen, Tan, Kurpiewski and Cai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Tong, Jie Chen, Baosheng Tan, Peng Wen Kurpiewski, Stephen Cai, Zhengxin Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases |
title | Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases |
title_full | Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases |
title_fullStr | Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases |
title_full_unstemmed | Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases |
title_short | Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases |
title_sort | poly (adp-ribose) polymerases as pet imaging targets for central nervous system diseases |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685622/ https://www.ncbi.nlm.nih.gov/pubmed/36438061 http://dx.doi.org/10.3389/fmed.2022.1062432 |
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