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The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review

In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies, and their experimental methods that provide insi...

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Autores principales: Shojaee, Pejman, Mornata, Federica, Deutsch, Andreas, Locati, Massimo, Hatzikirou, Haralampos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685623/
https://www.ncbi.nlm.nih.gov/pubmed/36439180
http://dx.doi.org/10.3389/fimmu.2022.1050067
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author Shojaee, Pejman
Mornata, Federica
Deutsch, Andreas
Locati, Massimo
Hatzikirou, Haralampos
author_facet Shojaee, Pejman
Mornata, Federica
Deutsch, Andreas
Locati, Massimo
Hatzikirou, Haralampos
author_sort Shojaee, Pejman
collection PubMed
description In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies, and their experimental methods that provide insights into tumor cell-macrophage interactions. We then focus on the mechanistic mathematical models describing the role of macrophages as drug carriers, the impact of macrophage polarized activation on tumor growth, and the role of tumor microenvironment (TME) parameters on the tumor-macrophage interactions. This review aims to identify the synergies between biological and mathematical approaches that allow us to translate knowledge on fundamental TAMs biology in addressing current clinical challenges.
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spelling pubmed-96856232022-11-25 The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review Shojaee, Pejman Mornata, Federica Deutsch, Andreas Locati, Massimo Hatzikirou, Haralampos Front Immunol Immunology In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies, and their experimental methods that provide insights into tumor cell-macrophage interactions. We then focus on the mechanistic mathematical models describing the role of macrophages as drug carriers, the impact of macrophage polarized activation on tumor growth, and the role of tumor microenvironment (TME) parameters on the tumor-macrophage interactions. This review aims to identify the synergies between biological and mathematical approaches that allow us to translate knowledge on fundamental TAMs biology in addressing current clinical challenges. Frontiers Media S.A. 2022-11-10 /pmc/articles/PMC9685623/ /pubmed/36439180 http://dx.doi.org/10.3389/fimmu.2022.1050067 Text en Copyright © 2022 Shojaee, Mornata, Deutsch, Locati and Hatzikirou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Shojaee, Pejman
Mornata, Federica
Deutsch, Andreas
Locati, Massimo
Hatzikirou, Haralampos
The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review
title The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review
title_full The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review
title_fullStr The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review
title_full_unstemmed The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review
title_short The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review
title_sort impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: a review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685623/
https://www.ncbi.nlm.nih.gov/pubmed/36439180
http://dx.doi.org/10.3389/fimmu.2022.1050067
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