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The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review
In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies, and their experimental methods that provide insi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685623/ https://www.ncbi.nlm.nih.gov/pubmed/36439180 http://dx.doi.org/10.3389/fimmu.2022.1050067 |
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author | Shojaee, Pejman Mornata, Federica Deutsch, Andreas Locati, Massimo Hatzikirou, Haralampos |
author_facet | Shojaee, Pejman Mornata, Federica Deutsch, Andreas Locati, Massimo Hatzikirou, Haralampos |
author_sort | Shojaee, Pejman |
collection | PubMed |
description | In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies, and their experimental methods that provide insights into tumor cell-macrophage interactions. We then focus on the mechanistic mathematical models describing the role of macrophages as drug carriers, the impact of macrophage polarized activation on tumor growth, and the role of tumor microenvironment (TME) parameters on the tumor-macrophage interactions. This review aims to identify the synergies between biological and mathematical approaches that allow us to translate knowledge on fundamental TAMs biology in addressing current clinical challenges. |
format | Online Article Text |
id | pubmed-9685623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96856232022-11-25 The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review Shojaee, Pejman Mornata, Federica Deutsch, Andreas Locati, Massimo Hatzikirou, Haralampos Front Immunol Immunology In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies, and their experimental methods that provide insights into tumor cell-macrophage interactions. We then focus on the mechanistic mathematical models describing the role of macrophages as drug carriers, the impact of macrophage polarized activation on tumor growth, and the role of tumor microenvironment (TME) parameters on the tumor-macrophage interactions. This review aims to identify the synergies between biological and mathematical approaches that allow us to translate knowledge on fundamental TAMs biology in addressing current clinical challenges. Frontiers Media S.A. 2022-11-10 /pmc/articles/PMC9685623/ /pubmed/36439180 http://dx.doi.org/10.3389/fimmu.2022.1050067 Text en Copyright © 2022 Shojaee, Mornata, Deutsch, Locati and Hatzikirou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Shojaee, Pejman Mornata, Federica Deutsch, Andreas Locati, Massimo Hatzikirou, Haralampos The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review |
title | The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review |
title_full | The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review |
title_fullStr | The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review |
title_full_unstemmed | The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review |
title_short | The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review |
title_sort | impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: a review |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685623/ https://www.ncbi.nlm.nih.gov/pubmed/36439180 http://dx.doi.org/10.3389/fimmu.2022.1050067 |
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