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Development of revised diagnostic criteria for Fuchs’ uveitis syndrome in a Chinese population

BACKGROUND/AIMS: Fuchs’ uveitis syndrome (FUS) is one of the frequently misdiagnosed uveitis entities, which is partly due to the absence of internationally recognised diagnostic criteria. This study was performed to develop and evaluate a set of revised diagnostic criteria for FUS. METHODS: The cli...

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Autores principales: Yang, Peizeng, Zhang, Wanyun, Chen, Zhijun, Zhang, Han, Su, Guannan, Cao, Qingfeng, Zhu, Ying, Zhong, Zhenyu, Zhou, Chunjiang, Wang, Yao, Kijlstra, Aize
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685691/
https://www.ncbi.nlm.nih.gov/pubmed/34108225
http://dx.doi.org/10.1136/bjophthalmol-2021-319343
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author Yang, Peizeng
Zhang, Wanyun
Chen, Zhijun
Zhang, Han
Su, Guannan
Cao, Qingfeng
Zhu, Ying
Zhong, Zhenyu
Zhou, Chunjiang
Wang, Yao
Kijlstra, Aize
author_facet Yang, Peizeng
Zhang, Wanyun
Chen, Zhijun
Zhang, Han
Su, Guannan
Cao, Qingfeng
Zhu, Ying
Zhong, Zhenyu
Zhou, Chunjiang
Wang, Yao
Kijlstra, Aize
author_sort Yang, Peizeng
collection PubMed
description BACKGROUND/AIMS: Fuchs’ uveitis syndrome (FUS) is one of the frequently misdiagnosed uveitis entities, which is partly due to the absence of internationally recognised diagnostic criteria. This study was performed to develop and evaluate a set of revised diagnostic criteria for FUS. METHODS: The clinical data of Chinese patients with FUS and patients with non-FUS were collected and analysed from a tertiary referral centre between April 2008 and December 2020. A total of 593 patients with FUS and 625 patients with non-FUS from northern China were enrolled for the development of diagnostic criteria for FUS. Three hundred and seventy-seven patients with FUS and 503 patients with non-FUS from southern China were used to validate the criteria. Clinical symptoms and ocular signs were collected from all patients with FUS and patients with non-FUS. Multivariate two-step cluster analysis, logistic regression and decision tree algorithms in combination with the clinical judgement of uveitis experts were used to revise diagnostic criteria for FUS. RESULTS: Three essential findings including diffuse iris depigmentation, absence of posterior synechiae, mild inflammation in the anterior chamber at presentation and five associated findings including mostly unilateral involvement, cataract, vitreous opacities, absence of acute symptoms and characteristic iris nodules were used in the development of FUS diagnostic criteria. All essential findings were required for the diagnosis of FUS, and the diagnosis was further strengthened by the presence of associated findings. CONCLUSION: Revised diagnostic criteria for FUS were developed and validated by analysing data from Chinese patients and showed a high sensitivity (96.55%) and specificity (97.42%).
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spelling pubmed-96856912022-11-25 Development of revised diagnostic criteria for Fuchs’ uveitis syndrome in a Chinese population Yang, Peizeng Zhang, Wanyun Chen, Zhijun Zhang, Han Su, Guannan Cao, Qingfeng Zhu, Ying Zhong, Zhenyu Zhou, Chunjiang Wang, Yao Kijlstra, Aize Br J Ophthalmol Clinical Science BACKGROUND/AIMS: Fuchs’ uveitis syndrome (FUS) is one of the frequently misdiagnosed uveitis entities, which is partly due to the absence of internationally recognised diagnostic criteria. This study was performed to develop and evaluate a set of revised diagnostic criteria for FUS. METHODS: The clinical data of Chinese patients with FUS and patients with non-FUS were collected and analysed from a tertiary referral centre between April 2008 and December 2020. A total of 593 patients with FUS and 625 patients with non-FUS from northern China were enrolled for the development of diagnostic criteria for FUS. Three hundred and seventy-seven patients with FUS and 503 patients with non-FUS from southern China were used to validate the criteria. Clinical symptoms and ocular signs were collected from all patients with FUS and patients with non-FUS. Multivariate two-step cluster analysis, logistic regression and decision tree algorithms in combination with the clinical judgement of uveitis experts were used to revise diagnostic criteria for FUS. RESULTS: Three essential findings including diffuse iris depigmentation, absence of posterior synechiae, mild inflammation in the anterior chamber at presentation and five associated findings including mostly unilateral involvement, cataract, vitreous opacities, absence of acute symptoms and characteristic iris nodules were used in the development of FUS diagnostic criteria. All essential findings were required for the diagnosis of FUS, and the diagnosis was further strengthened by the presence of associated findings. CONCLUSION: Revised diagnostic criteria for FUS were developed and validated by analysing data from Chinese patients and showed a high sensitivity (96.55%) and specificity (97.42%). BMJ Publishing Group 2022-12 2021-06-09 /pmc/articles/PMC9685691/ /pubmed/34108225 http://dx.doi.org/10.1136/bjophthalmol-2021-319343 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Clinical Science
Yang, Peizeng
Zhang, Wanyun
Chen, Zhijun
Zhang, Han
Su, Guannan
Cao, Qingfeng
Zhu, Ying
Zhong, Zhenyu
Zhou, Chunjiang
Wang, Yao
Kijlstra, Aize
Development of revised diagnostic criteria for Fuchs’ uveitis syndrome in a Chinese population
title Development of revised diagnostic criteria for Fuchs’ uveitis syndrome in a Chinese population
title_full Development of revised diagnostic criteria for Fuchs’ uveitis syndrome in a Chinese population
title_fullStr Development of revised diagnostic criteria for Fuchs’ uveitis syndrome in a Chinese population
title_full_unstemmed Development of revised diagnostic criteria for Fuchs’ uveitis syndrome in a Chinese population
title_short Development of revised diagnostic criteria for Fuchs’ uveitis syndrome in a Chinese population
title_sort development of revised diagnostic criteria for fuchs’ uveitis syndrome in a chinese population
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685691/
https://www.ncbi.nlm.nih.gov/pubmed/34108225
http://dx.doi.org/10.1136/bjophthalmol-2021-319343
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