Cargando…
Comprehensive genomic profiling of colorectal cancer patients reveals differences in mutational landscapes among clinical and pathological subgroups
With the widespread of colonoscopy, colorectal cancer remains to be one of the most detrimental types of cancer. Though there were multiple studies investigating the genomic landscape of colorectal cancer, a comprehensive analysis uncovering the differences between various types of colorectal cancer...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685809/ https://www.ncbi.nlm.nih.gov/pubmed/36439454 http://dx.doi.org/10.3389/fonc.2022.1000146 |
_version_ | 1784835600261578752 |
---|---|
author | Li, Peng Meng, Qingyu Xue, Yonggan Teng, Zhipeng Chen, Hanlin Zhang, Junli Xu, Yang Wang, Sha Yu, Ruoying Ou, Qiuxiang Wu, Xue Jia, Baoqing |
author_facet | Li, Peng Meng, Qingyu Xue, Yonggan Teng, Zhipeng Chen, Hanlin Zhang, Junli Xu, Yang Wang, Sha Yu, Ruoying Ou, Qiuxiang Wu, Xue Jia, Baoqing |
author_sort | Li, Peng |
collection | PubMed |
description | With the widespread of colonoscopy, colorectal cancer remains to be one of the most detrimental types of cancer. Though there were multiple studies investigating the genomic landscape of colorectal cancer, a comprehensive analysis uncovering the differences between various types of colorectal cancer is still lacking. In our study, we performed genomic analysis on 133 patients with colorectal cancer. Mutated FAT1 and PKHD1 and altered Hippo pathway genes were found to be enriched in early-onset colorectal cancer. APOBEC signature was prevalent in microsatellite stable (MSS) patients and was related to lymph node metastasis. ZNF217 mutations were significantly associated with early-stage colorectal cancer. In all, this study represents a comprehensive genomic analysis uncovering potential molecular mechanisms underneath different subgroups of colorectal cancer thus providing new targets for precision treatment development. |
format | Online Article Text |
id | pubmed-9685809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96858092022-11-25 Comprehensive genomic profiling of colorectal cancer patients reveals differences in mutational landscapes among clinical and pathological subgroups Li, Peng Meng, Qingyu Xue, Yonggan Teng, Zhipeng Chen, Hanlin Zhang, Junli Xu, Yang Wang, Sha Yu, Ruoying Ou, Qiuxiang Wu, Xue Jia, Baoqing Front Oncol Oncology With the widespread of colonoscopy, colorectal cancer remains to be one of the most detrimental types of cancer. Though there were multiple studies investigating the genomic landscape of colorectal cancer, a comprehensive analysis uncovering the differences between various types of colorectal cancer is still lacking. In our study, we performed genomic analysis on 133 patients with colorectal cancer. Mutated FAT1 and PKHD1 and altered Hippo pathway genes were found to be enriched in early-onset colorectal cancer. APOBEC signature was prevalent in microsatellite stable (MSS) patients and was related to lymph node metastasis. ZNF217 mutations were significantly associated with early-stage colorectal cancer. In all, this study represents a comprehensive genomic analysis uncovering potential molecular mechanisms underneath different subgroups of colorectal cancer thus providing new targets for precision treatment development. Frontiers Media S.A. 2022-11-10 /pmc/articles/PMC9685809/ /pubmed/36439454 http://dx.doi.org/10.3389/fonc.2022.1000146 Text en Copyright © 2022 Li, Meng, Xue, Teng, Chen, Zhang, Xu, Wang, Yu, Ou, Wu and Jia https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Li, Peng Meng, Qingyu Xue, Yonggan Teng, Zhipeng Chen, Hanlin Zhang, Junli Xu, Yang Wang, Sha Yu, Ruoying Ou, Qiuxiang Wu, Xue Jia, Baoqing Comprehensive genomic profiling of colorectal cancer patients reveals differences in mutational landscapes among clinical and pathological subgroups |
title | Comprehensive genomic profiling of colorectal cancer patients reveals differences in mutational landscapes among clinical and pathological subgroups |
title_full | Comprehensive genomic profiling of colorectal cancer patients reveals differences in mutational landscapes among clinical and pathological subgroups |
title_fullStr | Comprehensive genomic profiling of colorectal cancer patients reveals differences in mutational landscapes among clinical and pathological subgroups |
title_full_unstemmed | Comprehensive genomic profiling of colorectal cancer patients reveals differences in mutational landscapes among clinical and pathological subgroups |
title_short | Comprehensive genomic profiling of colorectal cancer patients reveals differences in mutational landscapes among clinical and pathological subgroups |
title_sort | comprehensive genomic profiling of colorectal cancer patients reveals differences in mutational landscapes among clinical and pathological subgroups |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685809/ https://www.ncbi.nlm.nih.gov/pubmed/36439454 http://dx.doi.org/10.3389/fonc.2022.1000146 |
work_keys_str_mv | AT lipeng comprehensivegenomicprofilingofcolorectalcancerpatientsrevealsdifferencesinmutationallandscapesamongclinicalandpathologicalsubgroups AT mengqingyu comprehensivegenomicprofilingofcolorectalcancerpatientsrevealsdifferencesinmutationallandscapesamongclinicalandpathologicalsubgroups AT xueyonggan comprehensivegenomicprofilingofcolorectalcancerpatientsrevealsdifferencesinmutationallandscapesamongclinicalandpathologicalsubgroups AT tengzhipeng comprehensivegenomicprofilingofcolorectalcancerpatientsrevealsdifferencesinmutationallandscapesamongclinicalandpathologicalsubgroups AT chenhanlin comprehensivegenomicprofilingofcolorectalcancerpatientsrevealsdifferencesinmutationallandscapesamongclinicalandpathologicalsubgroups AT zhangjunli comprehensivegenomicprofilingofcolorectalcancerpatientsrevealsdifferencesinmutationallandscapesamongclinicalandpathologicalsubgroups AT xuyang comprehensivegenomicprofilingofcolorectalcancerpatientsrevealsdifferencesinmutationallandscapesamongclinicalandpathologicalsubgroups AT wangsha comprehensivegenomicprofilingofcolorectalcancerpatientsrevealsdifferencesinmutationallandscapesamongclinicalandpathologicalsubgroups AT yuruoying comprehensivegenomicprofilingofcolorectalcancerpatientsrevealsdifferencesinmutationallandscapesamongclinicalandpathologicalsubgroups AT ouqiuxiang comprehensivegenomicprofilingofcolorectalcancerpatientsrevealsdifferencesinmutationallandscapesamongclinicalandpathologicalsubgroups AT wuxue comprehensivegenomicprofilingofcolorectalcancerpatientsrevealsdifferencesinmutationallandscapesamongclinicalandpathologicalsubgroups AT jiabaoqing comprehensivegenomicprofilingofcolorectalcancerpatientsrevealsdifferencesinmutationallandscapesamongclinicalandpathologicalsubgroups |