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First autochthonous clinical case of Hepatozoon silvestris in a domestic cat in Italy with unusual presentation
Hepatozoon spp. is the causative agent of a vector-borne parasitic disease in many animal species. In felids, Hepatozoon felis, Hepatozoon canis and Hepatozoon silvestris have been molecularly isolated. Hepatozoonosis usually causes asymptomatic infections in domestic cats, but clinical cases have r...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685847/ https://www.ncbi.nlm.nih.gov/pubmed/36419134 http://dx.doi.org/10.1186/s13071-022-05534-x |
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author | Simonato, Giulia Franco, Vittoria Salvatore, Giovanna Manzocchi, Simone Dotto, Giorgia Morelli, Simone Grillini, Marika Cavicchioli, Laura Gelain, Maria Elena Zini, Eric |
author_facet | Simonato, Giulia Franco, Vittoria Salvatore, Giovanna Manzocchi, Simone Dotto, Giorgia Morelli, Simone Grillini, Marika Cavicchioli, Laura Gelain, Maria Elena Zini, Eric |
author_sort | Simonato, Giulia |
collection | PubMed |
description | Hepatozoon spp. is the causative agent of a vector-borne parasitic disease in many animal species. In felids, Hepatozoon felis, Hepatozoon canis and Hepatozoon silvestris have been molecularly isolated. Hepatozoonosis usually causes asymptomatic infections in domestic cats, but clinical cases have recently been reported in Europe. We describe the first Italian case of hepatozoonosis in a cat with an unusual presentation. An 11-year-old neutered European shorthair cat was urgently hospitalized for intestinal intussusception. Hematology, biochemistry, FIV-FeLV tests, blood smears and molecular investigation targeting the 18S rRNA gene of Hepatozoon spp. were performed on blood samples; in addition, histological and molecular investigations were performed to analyze surgical samples to identify Hepatozoon infection. Hepatozoon gamonts were detected in granulocytes in the blood smear, and Hepatozoon spp. DNA was confirmed by PCR on blood. The intussusception was caused by a sessile endoluminal nodule that was surgically removed. Histologically, many elements referring to parasitic tissue forms were identified in the intestinal cells, and then the specimens were molecularly confirmed to harbor H. silvestris. This is the first description of symptomatic hepatozoonosis in a domestic cat in Italy. Hepatozoon silvestris has been described in wild felids, which are usually resilient to the infection, whereas the domestic cat seems to be more susceptible. Indeed, H. silvestris in cats usually presents tropism for skeletal muscle and myocardium with subsequent clinical manifestations. This is the first description of a domestic cat with H. silvestris localized in the intestinal epithelium and associated with intussusception. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-9685847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-96858472022-11-25 First autochthonous clinical case of Hepatozoon silvestris in a domestic cat in Italy with unusual presentation Simonato, Giulia Franco, Vittoria Salvatore, Giovanna Manzocchi, Simone Dotto, Giorgia Morelli, Simone Grillini, Marika Cavicchioli, Laura Gelain, Maria Elena Zini, Eric Parasit Vectors Brief Report Hepatozoon spp. is the causative agent of a vector-borne parasitic disease in many animal species. In felids, Hepatozoon felis, Hepatozoon canis and Hepatozoon silvestris have been molecularly isolated. Hepatozoonosis usually causes asymptomatic infections in domestic cats, but clinical cases have recently been reported in Europe. We describe the first Italian case of hepatozoonosis in a cat with an unusual presentation. An 11-year-old neutered European shorthair cat was urgently hospitalized for intestinal intussusception. Hematology, biochemistry, FIV-FeLV tests, blood smears and molecular investigation targeting the 18S rRNA gene of Hepatozoon spp. were performed on blood samples; in addition, histological and molecular investigations were performed to analyze surgical samples to identify Hepatozoon infection. Hepatozoon gamonts were detected in granulocytes in the blood smear, and Hepatozoon spp. DNA was confirmed by PCR on blood. The intussusception was caused by a sessile endoluminal nodule that was surgically removed. Histologically, many elements referring to parasitic tissue forms were identified in the intestinal cells, and then the specimens were molecularly confirmed to harbor H. silvestris. This is the first description of symptomatic hepatozoonosis in a domestic cat in Italy. Hepatozoon silvestris has been described in wild felids, which are usually resilient to the infection, whereas the domestic cat seems to be more susceptible. Indeed, H. silvestris in cats usually presents tropism for skeletal muscle and myocardium with subsequent clinical manifestations. This is the first description of a domestic cat with H. silvestris localized in the intestinal epithelium and associated with intussusception. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2022-11-23 /pmc/articles/PMC9685847/ /pubmed/36419134 http://dx.doi.org/10.1186/s13071-022-05534-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Brief Report Simonato, Giulia Franco, Vittoria Salvatore, Giovanna Manzocchi, Simone Dotto, Giorgia Morelli, Simone Grillini, Marika Cavicchioli, Laura Gelain, Maria Elena Zini, Eric First autochthonous clinical case of Hepatozoon silvestris in a domestic cat in Italy with unusual presentation |
title | First autochthonous clinical case of Hepatozoon silvestris in a domestic cat in Italy with unusual presentation |
title_full | First autochthonous clinical case of Hepatozoon silvestris in a domestic cat in Italy with unusual presentation |
title_fullStr | First autochthonous clinical case of Hepatozoon silvestris in a domestic cat in Italy with unusual presentation |
title_full_unstemmed | First autochthonous clinical case of Hepatozoon silvestris in a domestic cat in Italy with unusual presentation |
title_short | First autochthonous clinical case of Hepatozoon silvestris in a domestic cat in Italy with unusual presentation |
title_sort | first autochthonous clinical case of hepatozoon silvestris in a domestic cat in italy with unusual presentation |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685847/ https://www.ncbi.nlm.nih.gov/pubmed/36419134 http://dx.doi.org/10.1186/s13071-022-05534-x |
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