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Enhancement of acarbose production by genetic engineering and fed-batch fermentation strategy in Actinoplanes sp. SIPI12-34

BACKGROUND: Acarbose, as an alpha-glucosidase inhibitor, is widely used clinically to treat type II diabetes. In its industrial production, Actinoplanes sp. SE50/110 is used as the production strain. Lack of research on its regulatory mechanisms and unexplored gene targets are major obstacles to rat...

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Detalles Bibliográficos
Autores principales:	Li, Zhenxin, Yang, Songbai, Zhang, Zhengyu, Wu, Yuanjie, Tang, Jiawei, Wang, Luoju, Chen, Shaoxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685945/ https://www.ncbi.nlm.nih.gov/pubmed/36419063 http://dx.doi.org/10.1186/s12934-022-01969-0

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