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International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat

BACKGROUND: Benzydamine hydrochloride is a locally-acting Non-Steroidal Anti-Inflammatory Drug (NSAID) with combined local anesthetic and analgesic properties, indicated for the symptomatic relief of pain in acute sore throat. The aim of this study was to obtain an European Consensus among pharmacis...

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Autores principales: Passali, Desiderio, Barat, Veronica, Cadevall, Olga, Freire, Hugo Miguel, Grattagliano, Ignazio, Gutu, Ioan, Mösges, Ralph, Pavlysh, Andrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685970/
https://www.ncbi.nlm.nih.gov/pubmed/36419002
http://dx.doi.org/10.1186/s12875-022-01901-w
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author Passali, Desiderio
Barat, Veronica
Cadevall, Olga
Freire, Hugo Miguel
Grattagliano, Ignazio
Gutu, Ioan
Mösges, Ralph
Pavlysh, Andrey
author_facet Passali, Desiderio
Barat, Veronica
Cadevall, Olga
Freire, Hugo Miguel
Grattagliano, Ignazio
Gutu, Ioan
Mösges, Ralph
Pavlysh, Andrey
author_sort Passali, Desiderio
collection PubMed
description BACKGROUND: Benzydamine hydrochloride is a locally-acting Non-Steroidal Anti-Inflammatory Drug (NSAID) with combined local anesthetic and analgesic properties, indicated for the symptomatic relief of pain in acute sore throat. The aim of this study was to obtain an European Consensus among pharmacists, general practitioners and pediatricians on the appropriate use of benzydamine hydrochloride in the treatment of sore throat. METHODS: The authors developed a Delphi questionnaire organized into 15 statements focused on 4 topics: the mechanism of action of benzydamine, the benzydamine treatment in an adult patient and in a pediatric patient, and the advantages of benzydamine over other topical treatments. The survey was administered to a panel of to 320 participants including general practitioners, pediatricians, and pharmacists from 6 European countries (Italy, Germany, Portugal, Romania, Russia, and Spain), who rated their level of agreement or disagreement with each statement on a 6-point Likert scale. Consensus was predefined as more than 66% of the panel agreeing/disagreeing with each statement. RESULTS: Panelists’ agreement on statements was very high. Consensus was reached for all 15 statements in the Delphi survey, with more than 98% positive agreement on topic 4, suggesting a shared view among European healthcare professionals (HCPs) about the advantages of benzydamine over other topical treatments. A strong consensus (> 99%) was reached for all the statements of topic 1 regarding the mechanism of action of benzydamine, except for its anesthetic properties (79%). Strong agreement was reached for all statements in topics 2 and 3 regarding the treatment of acute sore throat symptoms in the adult and pediatric patient, except for one on the efficacy of benzydamine in preventing post-operative sore throat, for which it was 67%. CONCLUSION: Because all relevant publications on benzydamine are dated and there are no recommendations on its use for the symptomatic treatment of sore throat in European guidelines, this Delphi-based international consensus may be important in reinforcing the appropriate use and effect of benzydamine in the treatment of sore throat among health care professionals.
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spelling pubmed-96859702022-11-25 International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat Passali, Desiderio Barat, Veronica Cadevall, Olga Freire, Hugo Miguel Grattagliano, Ignazio Gutu, Ioan Mösges, Ralph Pavlysh, Andrey BMC Prim Care Research BACKGROUND: Benzydamine hydrochloride is a locally-acting Non-Steroidal Anti-Inflammatory Drug (NSAID) with combined local anesthetic and analgesic properties, indicated for the symptomatic relief of pain in acute sore throat. The aim of this study was to obtain an European Consensus among pharmacists, general practitioners and pediatricians on the appropriate use of benzydamine hydrochloride in the treatment of sore throat. METHODS: The authors developed a Delphi questionnaire organized into 15 statements focused on 4 topics: the mechanism of action of benzydamine, the benzydamine treatment in an adult patient and in a pediatric patient, and the advantages of benzydamine over other topical treatments. The survey was administered to a panel of to 320 participants including general practitioners, pediatricians, and pharmacists from 6 European countries (Italy, Germany, Portugal, Romania, Russia, and Spain), who rated their level of agreement or disagreement with each statement on a 6-point Likert scale. Consensus was predefined as more than 66% of the panel agreeing/disagreeing with each statement. RESULTS: Panelists’ agreement on statements was very high. Consensus was reached for all 15 statements in the Delphi survey, with more than 98% positive agreement on topic 4, suggesting a shared view among European healthcare professionals (HCPs) about the advantages of benzydamine over other topical treatments. A strong consensus (> 99%) was reached for all the statements of topic 1 regarding the mechanism of action of benzydamine, except for its anesthetic properties (79%). Strong agreement was reached for all statements in topics 2 and 3 regarding the treatment of acute sore throat symptoms in the adult and pediatric patient, except for one on the efficacy of benzydamine in preventing post-operative sore throat, for which it was 67%. CONCLUSION: Because all relevant publications on benzydamine are dated and there are no recommendations on its use for the symptomatic treatment of sore throat in European guidelines, this Delphi-based international consensus may be important in reinforcing the appropriate use and effect of benzydamine in the treatment of sore throat among health care professionals. BioMed Central 2022-11-23 /pmc/articles/PMC9685970/ /pubmed/36419002 http://dx.doi.org/10.1186/s12875-022-01901-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Passali, Desiderio
Barat, Veronica
Cadevall, Olga
Freire, Hugo Miguel
Grattagliano, Ignazio
Gutu, Ioan
Mösges, Ralph
Pavlysh, Andrey
International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat
title International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat
title_full International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat
title_fullStr International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat
title_full_unstemmed International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat
title_short International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat
title_sort international delphi-based consensus on the appropriate use and effect of benzydamine hydrochloride in the treatment of sore throat
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685970/
https://www.ncbi.nlm.nih.gov/pubmed/36419002
http://dx.doi.org/10.1186/s12875-022-01901-w
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