Molecular mechanism of circRNAs in drug resistance in renal cell carcinoma

Renal cell carcinoma (RCC) is one of the most common malignant tumors with a poor response to radiotherapy and chemotherapy. The advent of molecular targeted drugs has initiated great breakthroughs in the treatment of RCC. However, drug resistance to targeted drugs has become an urgent problem. Vari...

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Autores principales: Qin, Shuang, Wang, Yuting, Wang, Peijun, Lv, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686082/
https://www.ncbi.nlm.nih.gov/pubmed/36424596
http://dx.doi.org/10.1186/s12935-022-02790-w
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author Qin, Shuang
Wang, Yuting
Wang, Peijun
Lv, Qi
author_facet Qin, Shuang
Wang, Yuting
Wang, Peijun
Lv, Qi
author_sort Qin, Shuang
collection PubMed
description Renal cell carcinoma (RCC) is one of the most common malignant tumors with a poor response to radiotherapy and chemotherapy. The advent of molecular targeted drugs has initiated great breakthroughs in the treatment of RCC. However, drug resistance to targeted drugs has become an urgent problem. Various studies across the decades have confirmed the involvement of circular RNAs (circRNAs) in multiple pathophysiological processes and its abnormal expression in many malignant tumors. This review speculated that circRNAs can provide a new solution to drug resistance in RCC and perhaps be used as essential markers for the early diagnosis and prognosis of RCC. Through the analysis and discussion of relevant recent research, this review explored the relationship of circRNAs to and their regulatory mechanisms in drug resistance in RCC. The results indicate an association between the expression of circRNAs and the development of RCC, as well as the involvement of circRNAs in drug resistance in RCC.
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spelling pubmed-96860822022-11-25 Molecular mechanism of circRNAs in drug resistance in renal cell carcinoma Qin, Shuang Wang, Yuting Wang, Peijun Lv, Qi Cancer Cell Int Review Renal cell carcinoma (RCC) is one of the most common malignant tumors with a poor response to radiotherapy and chemotherapy. The advent of molecular targeted drugs has initiated great breakthroughs in the treatment of RCC. However, drug resistance to targeted drugs has become an urgent problem. Various studies across the decades have confirmed the involvement of circular RNAs (circRNAs) in multiple pathophysiological processes and its abnormal expression in many malignant tumors. This review speculated that circRNAs can provide a new solution to drug resistance in RCC and perhaps be used as essential markers for the early diagnosis and prognosis of RCC. Through the analysis and discussion of relevant recent research, this review explored the relationship of circRNAs to and their regulatory mechanisms in drug resistance in RCC. The results indicate an association between the expression of circRNAs and the development of RCC, as well as the involvement of circRNAs in drug resistance in RCC. BioMed Central 2022-11-24 /pmc/articles/PMC9686082/ /pubmed/36424596 http://dx.doi.org/10.1186/s12935-022-02790-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Qin, Shuang
Wang, Yuting
Wang, Peijun
Lv, Qi
Molecular mechanism of circRNAs in drug resistance in renal cell carcinoma
title Molecular mechanism of circRNAs in drug resistance in renal cell carcinoma
title_full Molecular mechanism of circRNAs in drug resistance in renal cell carcinoma
title_fullStr Molecular mechanism of circRNAs in drug resistance in renal cell carcinoma
title_full_unstemmed Molecular mechanism of circRNAs in drug resistance in renal cell carcinoma
title_short Molecular mechanism of circRNAs in drug resistance in renal cell carcinoma
title_sort molecular mechanism of circrnas in drug resistance in renal cell carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686082/
https://www.ncbi.nlm.nih.gov/pubmed/36424596
http://dx.doi.org/10.1186/s12935-022-02790-w
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