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Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021

Increasing evidence demonstrated that the ketogenic diet (KD) played a positive effect on cancer treatment. However, no systematic review and bibliometric analysis were conducted in this field. This study aimed to explore the current status, and reveal the potential trends and hotspots to provide a...

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Detalles Bibliográficos
Autores principales: Li, Rongrong, Huang, Qingcheng, Ye, Chenxiao, Wu, Changhong, Luo, Ning, Lu, Yi, Fang, Jianqiao, Wang, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686384/
https://www.ncbi.nlm.nih.gov/pubmed/36438725
http://dx.doi.org/10.3389/fnut.2022.1060436
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author Li, Rongrong
Huang, Qingcheng
Ye, Chenxiao
Wu, Changhong
Luo, Ning
Lu, Yi
Fang, Jianqiao
Wang, Yun
author_facet Li, Rongrong
Huang, Qingcheng
Ye, Chenxiao
Wu, Changhong
Luo, Ning
Lu, Yi
Fang, Jianqiao
Wang, Yun
author_sort Li, Rongrong
collection PubMed
description Increasing evidence demonstrated that the ketogenic diet (KD) played a positive effect on cancer treatment. However, no systematic review and bibliometric analysis were conducted in this field. This study aimed to explore the current status, and reveal the potential trends and hotspots to provide a reference for future research. Publications were extracted from the Web of Science Core Collection. CiteSpace (5.6.R3) software and the website of bibliometrics were used for visual analysis. A total of 500 publications with 334 articles and 166 reviews were included, with the timespan of 2012 to 2021. The United States was the most productive country. Majority of the top 10 institutions were from the United States, and Harvard University was the top-contributing institution. The most prolific author and the co-cited author was Thomas N Seyfried from Boston College. The highest cited reference was published in PLoS ONE, authored by Abdelwahab Mohammed G, with 161 citations. Glioma and breast cancer were the most common types of cancer in this field, while hepatocellular carcinoma and pancreatic cancer were the new hotspots. The anti-tumor mechanism of KD mainly focused on regulating metabolism, decanoic acid, oxidative stress, fatty acid oxidation, and cell apoptosis. Additionally, the presence of “chemotherapy” and “radiotherapy” in the keywords indicated that KD combined with anti-tumor research was a topic, while “immunotherapy” has became a recent frontiers. Notably, as a metabolic therapy, KD was deserved more attention in the treatment of hepatocellular carcinoma and pancreatic cancer, and KD combined with immunotherapy was the new hotspot and frontier. Additionally, more molecular studies and high-quality uniformly, randomized, controlled clinical trials are urgently warranted to evaluate the effect of KD in multiple cancers.
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spelling pubmed-96863842022-11-25 Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021 Li, Rongrong Huang, Qingcheng Ye, Chenxiao Wu, Changhong Luo, Ning Lu, Yi Fang, Jianqiao Wang, Yun Front Nutr Nutrition Increasing evidence demonstrated that the ketogenic diet (KD) played a positive effect on cancer treatment. However, no systematic review and bibliometric analysis were conducted in this field. This study aimed to explore the current status, and reveal the potential trends and hotspots to provide a reference for future research. Publications were extracted from the Web of Science Core Collection. CiteSpace (5.6.R3) software and the website of bibliometrics were used for visual analysis. A total of 500 publications with 334 articles and 166 reviews were included, with the timespan of 2012 to 2021. The United States was the most productive country. Majority of the top 10 institutions were from the United States, and Harvard University was the top-contributing institution. The most prolific author and the co-cited author was Thomas N Seyfried from Boston College. The highest cited reference was published in PLoS ONE, authored by Abdelwahab Mohammed G, with 161 citations. Glioma and breast cancer were the most common types of cancer in this field, while hepatocellular carcinoma and pancreatic cancer were the new hotspots. The anti-tumor mechanism of KD mainly focused on regulating metabolism, decanoic acid, oxidative stress, fatty acid oxidation, and cell apoptosis. Additionally, the presence of “chemotherapy” and “radiotherapy” in the keywords indicated that KD combined with anti-tumor research was a topic, while “immunotherapy” has became a recent frontiers. Notably, as a metabolic therapy, KD was deserved more attention in the treatment of hepatocellular carcinoma and pancreatic cancer, and KD combined with immunotherapy was the new hotspot and frontier. Additionally, more molecular studies and high-quality uniformly, randomized, controlled clinical trials are urgently warranted to evaluate the effect of KD in multiple cancers. Frontiers Media S.A. 2022-11-10 /pmc/articles/PMC9686384/ /pubmed/36438725 http://dx.doi.org/10.3389/fnut.2022.1060436 Text en Copyright © 2022 Li, Huang, Ye, Wu, Luo, Lu, Fang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Li, Rongrong
Huang, Qingcheng
Ye, Chenxiao
Wu, Changhong
Luo, Ning
Lu, Yi
Fang, Jianqiao
Wang, Yun
Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021
title Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021
title_full Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021
title_fullStr Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021
title_full_unstemmed Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021
title_short Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021
title_sort bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686384/
https://www.ncbi.nlm.nih.gov/pubmed/36438725
http://dx.doi.org/10.3389/fnut.2022.1060436
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