Structural differences in 3C-like protease (Mpro) from SARS-CoV and SARS-CoV-2: molecular insights revealed by Molecular Dynamics Simulations

Novel coronavirus SARS-CoV-2 has infected millions of people with thousands of mortalities globally. The main protease (Mpro) is vital in processing replicase polyproteins. Both the CoV’s Mpro shares 97% identity, with 12 mutations, but none are present in the active site. Although many therapeutics...

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Detalles Bibliográficos
Autores principales: Parmar, Meet, Thumar, Ritik, Patel, Bhumi, Athar, Mohd, Jha, Prakash C., Patel, Dhaval
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686461/
https://www.ncbi.nlm.nih.gov/pubmed/36467259
http://dx.doi.org/10.1007/s11224-022-02089-6

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