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Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration
Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases. Because their pathogenesis is unclear, it is challenging to combat age-related diseases. Cellular senescence is a cel...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686487/ https://www.ncbi.nlm.nih.gov/pubmed/36358561 http://dx.doi.org/10.3390/antiox11112189 |
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author | Terao, Ryo Ahmed, Tazbir Suzumura, Ayana Terasaki, Hiroko |
author_facet | Terao, Ryo Ahmed, Tazbir Suzumura, Ayana Terasaki, Hiroko |
author_sort | Terao, Ryo |
collection | PubMed |
description | Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases. Because their pathogenesis is unclear, it is challenging to combat age-related diseases. Cellular senescence is a cellular response characterized by cell cycle arrest. Cellular senescence is an important contributor to aging and age-related diseases through the alteration of cellular function and the secretion of senescence-associated secretory phenotypes. As a driver of stress-induced premature senescence, oxidative stress triggers cellular senescence and age-related diseases by inducing senescence markers via reactive oxygen species and mitochondrial dysfunction. In this review, we focused on the mechanism of oxidative stress-induced senescence in retinal cells and its role in the pathogenesis of AMD. |
format | Online Article Text |
id | pubmed-9686487 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96864872022-11-25 Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration Terao, Ryo Ahmed, Tazbir Suzumura, Ayana Terasaki, Hiroko Antioxidants (Basel) Review Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases. Because their pathogenesis is unclear, it is challenging to combat age-related diseases. Cellular senescence is a cellular response characterized by cell cycle arrest. Cellular senescence is an important contributor to aging and age-related diseases through the alteration of cellular function and the secretion of senescence-associated secretory phenotypes. As a driver of stress-induced premature senescence, oxidative stress triggers cellular senescence and age-related diseases by inducing senescence markers via reactive oxygen species and mitochondrial dysfunction. In this review, we focused on the mechanism of oxidative stress-induced senescence in retinal cells and its role in the pathogenesis of AMD. MDPI 2022-11-05 /pmc/articles/PMC9686487/ /pubmed/36358561 http://dx.doi.org/10.3390/antiox11112189 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Terao, Ryo Ahmed, Tazbir Suzumura, Ayana Terasaki, Hiroko Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration |
title | Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration |
title_full | Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration |
title_fullStr | Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration |
title_full_unstemmed | Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration |
title_short | Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration |
title_sort | oxidative stress-induced cellular senescence in aging retina and age-related macular degeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686487/ https://www.ncbi.nlm.nih.gov/pubmed/36358561 http://dx.doi.org/10.3390/antiox11112189 |
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