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Metabolism Profile of Mequindox in Sea Cucumbers In Vivo Using LC-HRMS

In this work, the metabolism behavior of mequindox (MEQ) in sea cucumber in vivo was investigated using LC-HRMS. In total, nine metabolites were detected and identified as well as the precursor in sea cucumber tissues. The metabolic pathways of MEQ in sea cucumber mainly include hydrogenation reduct...

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Autores principales: Mao, Xin, Zhou, Xiaozhen, He, Jun, Liu, Gongzhen, Liu, Huihui, Zhao, Han, Luo, Pengjie, Wu, Yongning, Li, Yanshen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686589/
https://www.ncbi.nlm.nih.gov/pubmed/36421242
http://dx.doi.org/10.3390/antibiotics11111599
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author Mao, Xin
Zhou, Xiaozhen
He, Jun
Liu, Gongzhen
Liu, Huihui
Zhao, Han
Luo, Pengjie
Wu, Yongning
Li, Yanshen
author_facet Mao, Xin
Zhou, Xiaozhen
He, Jun
Liu, Gongzhen
Liu, Huihui
Zhao, Han
Luo, Pengjie
Wu, Yongning
Li, Yanshen
author_sort Mao, Xin
collection PubMed
description In this work, the metabolism behavior of mequindox (MEQ) in sea cucumber in vivo was investigated using LC-HRMS. In total, nine metabolites were detected and identified as well as the precursor in sea cucumber tissues. The metabolic pathways of MEQ in sea cucumber mainly include hydrogenation reduction, deoxidation, carboxylation, deacetylation, and combinations thereof. The most predominant metabolites of MEQ in sea cucumber are 2-iso-BDMEQ and 2-iso-1-DMEQ, with deoxidation and carbonyl reduction as major metabolic pathways. In particular, this work first reported 3-methyl-2-quinoxalinecarboxylic acid (MQCA) as a metabolite of MEQ, and carboxylation is a major metabolic pathway of MEQ in sea cucumber. This work revealed that the metabolism of MEQ in marine animals is different from that in land animals. The metabolism results in this work could facilitate the accurate risk assessment of MEQ in sea cucumber and related marine foods.
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spelling pubmed-96865892022-11-25 Metabolism Profile of Mequindox in Sea Cucumbers In Vivo Using LC-HRMS Mao, Xin Zhou, Xiaozhen He, Jun Liu, Gongzhen Liu, Huihui Zhao, Han Luo, Pengjie Wu, Yongning Li, Yanshen Antibiotics (Basel) Article In this work, the metabolism behavior of mequindox (MEQ) in sea cucumber in vivo was investigated using LC-HRMS. In total, nine metabolites were detected and identified as well as the precursor in sea cucumber tissues. The metabolic pathways of MEQ in sea cucumber mainly include hydrogenation reduction, deoxidation, carboxylation, deacetylation, and combinations thereof. The most predominant metabolites of MEQ in sea cucumber are 2-iso-BDMEQ and 2-iso-1-DMEQ, with deoxidation and carbonyl reduction as major metabolic pathways. In particular, this work first reported 3-methyl-2-quinoxalinecarboxylic acid (MQCA) as a metabolite of MEQ, and carboxylation is a major metabolic pathway of MEQ in sea cucumber. This work revealed that the metabolism of MEQ in marine animals is different from that in land animals. The metabolism results in this work could facilitate the accurate risk assessment of MEQ in sea cucumber and related marine foods. MDPI 2022-11-11 /pmc/articles/PMC9686589/ /pubmed/36421242 http://dx.doi.org/10.3390/antibiotics11111599 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mao, Xin
Zhou, Xiaozhen
He, Jun
Liu, Gongzhen
Liu, Huihui
Zhao, Han
Luo, Pengjie
Wu, Yongning
Li, Yanshen
Metabolism Profile of Mequindox in Sea Cucumbers In Vivo Using LC-HRMS
title Metabolism Profile of Mequindox in Sea Cucumbers In Vivo Using LC-HRMS
title_full Metabolism Profile of Mequindox in Sea Cucumbers In Vivo Using LC-HRMS
title_fullStr Metabolism Profile of Mequindox in Sea Cucumbers In Vivo Using LC-HRMS
title_full_unstemmed Metabolism Profile of Mequindox in Sea Cucumbers In Vivo Using LC-HRMS
title_short Metabolism Profile of Mequindox in Sea Cucumbers In Vivo Using LC-HRMS
title_sort metabolism profile of mequindox in sea cucumbers in vivo using lc-hrms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686589/
https://www.ncbi.nlm.nih.gov/pubmed/36421242
http://dx.doi.org/10.3390/antibiotics11111599
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